Clinical outcome of pelvic exenteration in patients with advanced or recurrent uterine cervical cancer

Sota Tanaka, Satoru Nagase, Michiko Kaiho-Sakuma, Tomoyuki Nagai, Hiroki Kurosawa, Masafumi Toyoshima, Hideki Tokunaga, Takeo Otsuki, Hiroki Utsunomiya, Tadao Takano, Hitoshi Niikura, Kiyoshi Ito, Nobuo Yaegashi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Background: Pelvic exenteration has attained an important role in the treatment of advanced or recurrent cervical cancer for obtaining a complete cure or longer disease-free survival. The purpose of this study was to evaluate patients undergoing pelvic exenteration and to determine the clinical features associated with outcome and survival. Methods: We retrospectively analyzed the records of 12 patients who underwent pelvic exenteration for uterine cervical cancer between July 2002 and August 2011. Results: Two patients had primary stage IVA cervical adenocarcinoma and 10 patients had recurrent cervical cancer. Eight patients underwent anterior pelvic exenteration, 3 patients underwent total pelvic exenteration, and 1 patient underwent posterior pelvic exenteration. With a median duration of follow-up of 22 months (range 3-116 months), 5 patients were alive without recurrence. Of 5 patients with no evidence of disease, 4 were recurrent or residual tumor, all of whom had common factors, such as a tumor size ≤30 mm, negative surgical margins, complete resection, and no lymph node involvement. The 5-year overall survival rate for 12 patients was 42.2 %. Ileus was the most common complication (42 %) and post-operative intestinal anastomosis leaks developed in 3 patients, but no ureteral anastomosis leaks occurred. Conclusions: Pelvic exenteration is a feasible surgical procedure in advanced and/or recurrent cervical cancer patients with no associated post-operative mortality, and the only therapeutic option for complete cure or long-term survival; however, post-operative complications frequently occur.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalInternational Journal of Clinical Oncology
Volume19
Issue number1
DOIs
Publication statusPublished - 2014 Feb

Keywords

  • Complications
  • Pelvic exenteration
  • Positron emission tomography/computed tomography
  • Urinary diversion
  • Uterine cervical cancer

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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