Clinical outcome of pelvic exenteration in patients with advanced or recurrent uterine cervical cancer

Sota Tanaka, Satoru Nagase, Michiko Kaiho, Tomoyuki Nagai, Hiroki Kurosawa, Masafumi Toyoshima, Hideki Tokunaga, Takeo Otsuki, Hiroki Utsunomiya, Tadao Takano, Hitoshi Niikura, Kiyoshi Ito, Nobuo Yaegashi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background: Pelvic exenteration has attained an important role in the treatment of advanced or recurrent cervical cancer for obtaining a complete cure or longer disease-free survival. The purpose of this study was to evaluate patients undergoing pelvic exenteration and to determine the clinical features associated with outcome and survival. Methods: We retrospectively analyzed the records of 12 patients who underwent pelvic exenteration for uterine cervical cancer between July 2002 and August 2011. Results: Two patients had primary stage IVA cervical adenocarcinoma and 10 patients had recurrent cervical cancer. Eight patients underwent anterior pelvic exenteration, 3 patients underwent total pelvic exenteration, and 1 patient underwent posterior pelvic exenteration. With a median duration of follow-up of 22 months (range 3-116 months), 5 patients were alive without recurrence. Of 5 patients with no evidence of disease, 4 were recurrent or residual tumor, all of whom had common factors, such as a tumor size ≤30 mm, negative surgical margins, complete resection, and no lymph node involvement. The 5-year overall survival rate for 12 patients was 42.2 %. Ileus was the most common complication (42 %) and post-operative intestinal anastomosis leaks developed in 3 patients, but no ureteral anastomosis leaks occurred. Conclusions: Pelvic exenteration is a feasible surgical procedure in advanced and/or recurrent cervical cancer patients with no associated post-operative mortality, and the only therapeutic option for complete cure or long-term survival; however, post-operative complications frequently occur.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalInternational Journal of Clinical Oncology
Volume19
Issue number1
DOIs
Publication statusPublished - 2014 Feb

Keywords

  • Complications
  • Pelvic exenteration
  • Positron emission tomography/computed tomography
  • Urinary diversion
  • Uterine cervical cancer

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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