Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus

Kazunari Ishii, Tomonori Kanda, Aya Harada, Naokazu Miyamoto, Tetsuro Kawaguchi, Kenichi Shimada, Shingo Ohkawa, Takafumi Uemura, Toshiki Yoshikawa, Etsuro Mori

Research output: Contribution to journalArticlepeer-review

94 Citations (Scopus)

Abstract

The utility of measuring the corpus callosal angle (CA) for the diagnosis of idiopathic normal pressure hydrocephalus (INPH) was investigated. Three-dimensional magnetic resonance imaging (MRI) was performed in 34 INPH patients, 34 Alzheimer's disease (AD) patients, and 34 normal control (NC) subjects. Measurement of the CA on the coronal MR images of the posterior commissure perpendicular to the anteroposterior commissure plane was performed for all subjects. The CA of the INPH group (mean±SD, 66 ± 14°) was significantly smaller than those of the AD (104 ± 15°) and NC (112-11°) groups. When using the threshold of the mean -2SD value of the NC group (= 90°), an accuracy of 93%, sensitivity of 97%, and specificity of 88% were observed for discrimination of INPH from AD patients. Measuring the CA helps in differentiating INPH patients from AD and normally aged subjects.

Original languageEnglish
Pages (from-to)2678-2683
Number of pages6
JournalEuropean Radiology
Volume18
Issue number11
DOIs
Publication statusPublished - 2008

Keywords

  • Alzheimer's disease
  • Callosal angle
  • Idiopathic normal pressure hydrocephalus (INPH)
  • Magnetic resonance imaging (MRI)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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