TY - JOUR
T1 - Clinical impact of lung age on postoperative complications in non-small cell lung cancer patients aged >70 y
AU - Ogawa, Fumihiro
AU - Miyata, Satoshi
AU - Nakashima, Hiroyasu
AU - Matsui, Yoshio
AU - Shiomi, Kazu
AU - Iyoda, Akira
AU - Satoh, Yukitoshi
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2014/5/15
Y1 - 2014/5/15
N2 - Background Surgery for elderly patients with primary lung neoplasms has become relatively common as populations age; however, the high frequency of postoperative complications has prevented its broad application. Recently, the Japanese Respiratory Society proposed lung age (LA) as an index of lung function, but reports on the association between LA and the risk factors for postoperative complications with non-small cell lung cancer (NSCLC) surgery have been limited. In this study, we analyzed the clinical applicability of LA for elderly patients with NSCLC. Materials and methods We studied 320 patients aged >70 y underwent curative resections for NSCLC. LA was calculated based on the formula provided by the Japanese Respiratory Society, which depended on the patient's preoperative respiratory function and was divided into four age gap (AG) groups between the LA and the true age (TA). The categorical data were compared among the four groups. Results The numbers of patients in groups A, B, C, and D were 80, 77, 79, and 84, respectively. For the univariate analysis, the preoperative factors for postoperative complications were gender, AG, and smoking (P < 0.05). In a multivariate analysis, AG proved to be an independent factor. Although we found no significant differences, there was a tendency for the prognosis to worsen with an increase in the AG (P = 0.06). Conclusions The AG was significantly associated with and an independent predictive factor for postoperative complications. We conclude that LA and AG are useful factors for predicting the risk of postoperative complications.
AB - Background Surgery for elderly patients with primary lung neoplasms has become relatively common as populations age; however, the high frequency of postoperative complications has prevented its broad application. Recently, the Japanese Respiratory Society proposed lung age (LA) as an index of lung function, but reports on the association between LA and the risk factors for postoperative complications with non-small cell lung cancer (NSCLC) surgery have been limited. In this study, we analyzed the clinical applicability of LA for elderly patients with NSCLC. Materials and methods We studied 320 patients aged >70 y underwent curative resections for NSCLC. LA was calculated based on the formula provided by the Japanese Respiratory Society, which depended on the patient's preoperative respiratory function and was divided into four age gap (AG) groups between the LA and the true age (TA). The categorical data were compared among the four groups. Results The numbers of patients in groups A, B, C, and D were 80, 77, 79, and 84, respectively. For the univariate analysis, the preoperative factors for postoperative complications were gender, AG, and smoking (P < 0.05). In a multivariate analysis, AG proved to be an independent factor. Although we found no significant differences, there was a tendency for the prognosis to worsen with an increase in the AG (P = 0.06). Conclusions The AG was significantly associated with and an independent predictive factor for postoperative complications. We conclude that LA and AG are useful factors for predicting the risk of postoperative complications.
KW - Age gap
KW - Lung age
KW - Non-small cell lung cancer
KW - Postoperative complications
KW - Prognosis
KW - Respiratory function
KW - Surgical resection
UR - http://www.scopus.com/inward/record.url?scp=84898818128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898818128&partnerID=8YFLogxK
U2 - 10.1016/j.jss.2014.01.012
DO - 10.1016/j.jss.2014.01.012
M3 - Article
C2 - 24503213
AN - SCOPUS:84898818128
VL - 188
SP - 373
EP - 380
JO - Journal of Surgical Research
JF - Journal of Surgical Research
SN - 0022-4804
IS - 2
ER -