Clinical impact of lung age on postoperative complications in non-small cell lung cancer patients aged >70 y

Fumihiro Ogawa, Satoshi Miyata, Hiroyasu Nakashima, Yoshio Matsui, Kazu Shiomi, Akira Iyoda, Yukitoshi Satoh

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background Surgery for elderly patients with primary lung neoplasms has become relatively common as populations age; however, the high frequency of postoperative complications has prevented its broad application. Recently, the Japanese Respiratory Society proposed lung age (LA) as an index of lung function, but reports on the association between LA and the risk factors for postoperative complications with non-small cell lung cancer (NSCLC) surgery have been limited. In this study, we analyzed the clinical applicability of LA for elderly patients with NSCLC. Materials and methods We studied 320 patients aged >70 y underwent curative resections for NSCLC. LA was calculated based on the formula provided by the Japanese Respiratory Society, which depended on the patient's preoperative respiratory function and was divided into four age gap (AG) groups between the LA and the true age (TA). The categorical data were compared among the four groups. Results The numbers of patients in groups A, B, C, and D were 80, 77, 79, and 84, respectively. For the univariate analysis, the preoperative factors for postoperative complications were gender, AG, and smoking (P < 0.05). In a multivariate analysis, AG proved to be an independent factor. Although we found no significant differences, there was a tendency for the prognosis to worsen with an increase in the AG (P = 0.06). Conclusions The AG was significantly associated with and an independent predictive factor for postoperative complications. We conclude that LA and AG are useful factors for predicting the risk of postoperative complications.

Original languageEnglish
Pages (from-to)373-380
Number of pages8
JournalJournal of Surgical Research
Volume188
Issue number2
DOIs
Publication statusPublished - 2014 May 15

Keywords

  • Age gap
  • Lung age
  • Non-small cell lung cancer
  • Postoperative complications
  • Prognosis
  • Respiratory function
  • Surgical resection

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Clinical impact of lung age on postoperative complications in non-small cell lung cancer patients aged >70 y'. Together they form a unique fingerprint.

Cite this