Clinical evaluations of complete autologous fibrin glue, produced by the CryoSeal® FS system, and polyglycolic acid sheets as wound coverings after oral surgery

Atsumu Kouketsu, Shinnosuke Nogami, Minami Yamada-Fujiwara, Hirokazu Nagai, Kensuke Yamauchi, Shiro Mori, Hitoshi Miyashita, Tadashi Kawai, Aritsune Matsui, Yoshihiro Kataoka, Norihisa Satomi, Yushi Ezoe, Satoko Abe, Yuri Takeda, Takeshi Tone, Bunnichi Hirayama, Tsuyoshi Kurobane, Kazuki Tashiro, Yuta Yanagisawa, Tetsu Takahashi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The CryoSeal® FS System has been recently introduced as an automated device for the production of complete fibrin glue from autologous plasma, rather than from pool allogenic or cattle blood, to prevent viral infection and allergic reaction. We evaluated the effectiveness of complete autologous fibrin glue and polyglycolic acid (PGA) sheet wound coverings in mucosa defect oral surgery. Postoperative pain, scar contracture, ingestion, tongue dyskinesia, and postoperative bleeding were evaluated in 12 patients who underwent oral (including the tongue) mucosa excision, and received a PGA sheet and an autologous fibrin glue covering. They were compared with 12 patients who received a PGA sheet and commercial allogenic fibrin glue. All cases in the complete autologous fibrin glue group demonstrated good wound healing without complications such as local infection or incomplete cure. All evaluated clinical measures in this group were similar or superior to the commercial allogenic fibrin glue group. Coagulation and adhesion quality achieved with this method was comparable to that with a PGA sheet and commercial fibrin glue. Covering oral surgery wounds with complete autologous fibrin glue produced by an automated device was convenient, safe, and reduced the risk of viral infection and allergic reaction associated with conventional techniques.

Original languageEnglish
Pages (from-to)1458-1463
Number of pages6
JournalJournal of Cranio-Maxillofacial Surgery
Volume45
Issue number9
DOIs
Publication statusPublished - 2017 Sep

Keywords

  • Fibrin glue
  • Oral mucosa
  • Oral surgery
  • Polyglycolic acid sheet

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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