Clinical efficacy of topical nipradilol and timolol on visual field performance in normal-tension glaucoma: A multicenter, randomized, double-masked comparative study

Makoto Araie, Shiroaki Shirato, Yoshio Yamazaki, Yoshiaki Kitazawa, Yasuo Ohashi, Takeshi Hara, Takako Hashimoto, Tadahiko Tsuru, Takayoshi Kojima, Atsuo Tomidokoro, Fumiko Nakajima, Ryo Obata, Takako Nakagami, Fukuko Hayamizu, Junkichi Yamagami, Junko Suzuki, Shuichi Kishimoto, Yuri Oshima, Kei Nakayama, Yuichiro OtakeItaru Kimura, Tomihiko Tanino, Mai Haneda, Tairo Kimura, Kiho Kawabata, Noriko Yasuda, Kenji Nakamoto, Shun Matsumoto, Miwako Yoshimoto, Hirotaka Suzumura, Goji Tomita, Yasuyuki Suzuki, Shiho Kunimatsu, Tadashi Nakano, Katsuhiko Maruyama, Toyoko Inoue, Ai Kouzaki, Yoichi Inoue, Keiji Yoshikawa, Hiroshi Miyata, Motohiro Shirakashi, Kenji Kashiwagi, Aiko Iwase, Yuko Shono

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11 Citations (Scopus)

Abstract

Purpose: To compare the effects of topical nipradilol and timolol on the visual field in Japanese normaltension glaucoma (NTG) patients. Methods: We enrolled 146 NTG patients. At baseline, age, intraocular pressure (IOP), and mean deviation (MD) by the Humphrey field analyzer were 47.6 (SD 8.5), 14.2 (1.7) mmHg, and -4.5 (3.0) dB. Seventy-two patients were randomly assigned to the 0.25% nipradilol group and 74 patients to the 0.5% timolol ophthalmic solution group twice daily for the 3-year study period. The Humphrey full-threshold 30-2 visual field test was performed every 6 months. The primary end point was the nonparametric O'Brien summary score (sum of the ranks of six slopes calculated from the average of the total deviation in each cluster) in each patient. The secondary analyses were differences in the MD slope, average of the total deviation in each cluster, the corrected pattern standard deviation (CPSD), and the time course of IOP. Results: No significant intergroup differences were found in baseline characteristics, or in the parameters of the primary and secondary analyses. In both groups, central superior clusters showed negative slopes and IOP decreased by about 1 mmHg from baseline. Conclusion: No significant difference in visual field performance or IOP reduction was seen between the nipradilol and timolol groups.

Original languageEnglish
Pages (from-to)255-264
Number of pages10
JournalJapanese Journal of Ophthalmology
Volume52
Issue number4
DOIs
Publication statusPublished - 2008 Jul

Keywords

  • Clinical trial
  • Glaucoma
  • Nipradilol
  • Timolol
  • Visual field

ASJC Scopus subject areas

  • Ophthalmology

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    Araie, M., Shirato, S., Yamazaki, Y., Kitazawa, Y., Ohashi, Y., Hara, T., Hashimoto, T., Tsuru, T., Kojima, T., Tomidokoro, A., Nakajima, F., Obata, R., Nakagami, T., Hayamizu, F., Yamagami, J., Suzuki, J., Kishimoto, S., Oshima, Y., Nakayama, K., ... Shono, Y. (2008). Clinical efficacy of topical nipradilol and timolol on visual field performance in normal-tension glaucoma: A multicenter, randomized, double-masked comparative study. Japanese Journal of Ophthalmology, 52(4), 255-264. https://doi.org/10.1007/s10384-008-0540-z