Clinical characteristics of idiopathic normal pressure hydrocephalus with Lewy body diseases

Hayato Odagiri, Toru Baba, Yoshiyuki Nishio, Osamu Iizuka, Wataru Narita, Minoru Matsuda, Etsuro Mori

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background Comorbidity of idiopathic normal pressure hydrocephalus and neurodegenerative diseases presents a diagnostic challenge. The aim of this study was to elucidate the clinical features of iNPH patients who are possibly comorbid with Lewy body diseases. Methods In this study, we retrospectively analyzed the records of consecutive 127 patients with definite idiopathic normal pressure hydrocephalus. 123I-Metaiodobenzylguanidine myocardial scintigraphy was undertaken to 21 patients with idiopathic normal pressure hydrocephalus because of suspicion for comorbid Lewy body diseases. Results As a result, 7 of the 21 patients with idiopathic normal pressure hydrocephalus exhibited cardiac sympathetic abnormality. Idiopathic normal pressure hydrocephalus patients with cardiac sympathetic dysfunction had the constellation of clinical findings, such as younger onset, less severe urinary dysfunction, kinesie paradoxale, and cogwheel rigidity. Conclusions Our results suggested that comorbidity of idiopathic normal pressure hydrocephalus and Lewy body diseases are not rare condition and careful screening for potentially-curative surgery is important especially in atypical cases.

Original languageEnglish
Pages (from-to)309-311
Number of pages3
JournalJournal of the neurological sciences
Volume359
Issue number1-2
DOIs
Publication statusPublished - 2015 Dec 15

Keywords

  • 123I-MIBG myocardial scintigraphy
  • Comorbidity
  • Dementia with Lewy bodies
  • Idiopathic normal pressure hydrocephalus
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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