Clinical characteristics of first-ever atherothrombotic infarction or lacunar with hyperlipidemia (J-STARS-C): An analysis of data from the stroke data bank of Japan

Eiichi Nomura, Tatsuo Kohriyama, Masayasu Matsumoto, Shotai Kobayashi, Takeshi Yamada, Isao Inobe, Masahiro Yamasaki, Koichi Hirata, Shiro Ohue, Takanori Ohnishi, Kenichiro Fujii, Hirofumi Abe, Setsuro Ibayashi, Ryuzo Fukunaga, Toshiyuki Uehara, Akira Ogawa, Naohisa Hosomi, Kazuya Nagata, Norio Tanahashi, Yoichiro HashimotoHiroaki Shimizu, Syuichi Sugiyama, Yasumasa Yamamoto, Jyoji Nakagawara, Kazuo Minematsu, Yasushi Okada, Yasuhiro Manabe, Katumi Irie, Shinichiro Uchiyama, Kazunori Okada, Tomohiko Sato, Junji Yoshioka, Masayuki Takeshima, Kazuo Kitagawa, Toru Kimura, Akifumi Suzuki, Yuichiro Inatomi, Nobuo Araki, Fusao Igawa, Kazuo Takahashi, Jinichi Koizumi, Yoshisuke Saku, Eiichi Nomura, Shinji Nagahiro, Yukito Shinohara, Yasuhisa Kitagawa, Shingo Oono, Makoto Takagi, Masaru Kuriyama, Shoichi Kato, Michiyasu Suzuki

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: The clinical trial, Japan Statin Treatment Against Recurrent Stroke (J-STARS), is being carried out to investigate the efficacy of statin treatment against recurrent stroke. To participate in J-STARS, patients must have a past history of ischemic stroke excluding cardioembolic events, and must be clinically diagnosed with hyperlipidemia (HL). Before starting J-STARS, we needed to be aware of the clinical characteristics of the patients who were eligible to participate in this study. Methods: Between 1999 and 2002, 7,149 patients with ischemic stroke were enrolled in a stroke data bank developed by the Japan Standard Stroke Registry Study Group. From this, we acquired the data on 1,487 patients with first-ever atherothrombotic infarction (ATI) or lacunar infarction (LI) with a satisfactory functional outcome on discharge. Results: Patients with HL were significantly younger (65.3±11.0 vs 68.4±10.9, p<0.0001) and showed a higher frequency of concomitant hypertension (70.9% vs 61.0%, p=0.0002), diabetes mellitus (42.2% vs 25.7%, p<0.0001) or both (31.7% vs 16.4%, p<0.0001) compared to those without HL. The ratio of ATI to LI and the frequency of prior ischemic heart disease (IHD) did not differ between the 2 groups. Among 467 patients with HL, 52.7% did not receive treatment on admission. Conclusion: ATI or LI patients with HL had an earlier age of onset and higher frequency of other lifestyle-related diseases, and this probably includes many with metabolic syndrome, whereas the frequency of IHD was not different between these 2 groups.

Original languageEnglish
Pages (from-to)1252-1257
Number of pages6
JournalInternal Medicine
Volume44
Issue number12
DOIs
Publication statusPublished - 2006 Jan 17

Keywords

  • Atherothrombotic infarction
  • Hyperlipidemia
  • J-STARS
  • J-STARS-C
  • Lacunar infarction
  • Stroke data bank

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint Dive into the research topics of 'Clinical characteristics of first-ever atherothrombotic infarction or lacunar with hyperlipidemia (J-STARS-C): An analysis of data from the stroke data bank of Japan'. Together they form a unique fingerprint.

  • Cite this

    Nomura, E., Kohriyama, T., Matsumoto, M., Kobayashi, S., Yamada, T., Inobe, I., Yamasaki, M., Hirata, K., Ohue, S., Ohnishi, T., Fujii, K., Abe, H., Ibayashi, S., Fukunaga, R., Uehara, T., Ogawa, A., Hosomi, N., Nagata, K., Tanahashi, N., ... Suzuki, M. (2006). Clinical characteristics of first-ever atherothrombotic infarction or lacunar with hyperlipidemia (J-STARS-C): An analysis of data from the stroke data bank of Japan. Internal Medicine, 44(12), 1252-1257. https://doi.org/10.2169/internalmedicine.44.1252