Clinical characteristics and risk factors for the development of postoperative hepatic steatosis after total pancreatectomy

Tatsuo Hata, Masaharu Ishida, Fuyuhiko Motoi, Naoaki Sakata, Gumpei Yoshimatsu, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Michiaki Unno

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Objectives: The occurrence of hepatic steatosis after pancreatectomy is known to be associated with the remnant pancreatic function. However, other risk factors for hepatic steatosis after pancreatectomy remain unknown. The aims of this study were to identify other risk factors in addition to the remnant pancreatic function and elucidate the relationship between postoperative hepatic steatosis and pancreatic exocrine insufficiency in totally pancreatomized patients. Methods: Forty-three patients who underwent total pancreatectomy were analyzed. Hepatic steatosis was defined as the attenuation of unenhanced computed tomography values. Clinical findings and laboratory data were compared between patients with and without hepatic steatosis. Results: Sixteen (37.2%) patients developed hepatic steatosis after total pancreatectomy, with marked declines in the Controlling Nutritional Status score and body mass index. Multiple linear regression analysis revealed that the attenuation of computed tomography values was correlated with female sex (P = 0.002), early postoperative serum albumin levels (P = 0.003), and pancreatic enzyme replacement therapy with high-dose pancrelipase (P = 0.032). Conclusions: Postoperative hepatic steatosis after pancreatectomy is associated with sex, malnutrition, and pancreatic exocrine insufficiency. High-dose pancreatic enzyme replacement therapy may have preventive effects on hepatic steatosis occurring after pancreatectomy.

Original languageEnglish
Pages (from-to)362-369
Number of pages8
Issue number3
Publication statusPublished - 2016


  • Controlling nutritional status score
  • Hepatic steatosis
  • Pancreatic enzyme replacement therapy
  • Pancreatic exocrine insufficiency
  • Pancrelipase
  • Total pancreatectomy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


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