Clinical characteristics and long-term prognosis of patients with variant angina. A comparative study between western and Japanese populations

Hiroaki Shimokawa, Kazushige Nagasawa, Takashi Irie, Shogo Egashira, Kensuke Egashira, Tomohiko Sagara, Yutaka Kikuchi, Motoomi Nakamura

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102 Citations (Scopus)

Abstract

To determine the factors influencing the prognosis of variant angina, the clinical characteristics and long-term prognosis of 158 consecutive Japanese patients were examined and compared with those in previous major western studies (Pisa, Montreal, and Duke studies). The Japanese patients were characterized by relatively low prevalences of coronary risk factors, significant coronary stenoses and previous myocardial infarction. Survival and survival without myocardial infarction for the entire group or for the subpopulation with significant coronary artery disease were significantly better in the Japanese population than in the western populations; however, in the subpopulation without significant coronary artery disease, the prognosis was excellent in all four studies. If the prevalence of coronary artery disease was corrected for the Japanese population, there would be no difference in the prognosis between the Japanese and the western populations. It is concluded: (1) the overall prognosis of variant angina may be better in Japanese patients, and (2) coronary artery disease appears to be the strongest prognostic factor for assessing the differences in the prognosis between the Japanese and the western populations.

Original languageEnglish
Pages (from-to)331-349
Number of pages19
JournalInternational Journal of Cardiology
Volume18
Issue number3
DOIs
Publication statusPublished - 1988 Mar

Keywords

  • Calcium channel blockers
  • Coronary artery spasm
  • Sudden death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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