Clinical application of62Zn/62Cu positron generator: Perfusion and plasma pool images in normal subjects

Hidehiko Okazawa, Yasuhisa Fujibayashi, Yoshiharu Yonekura, Nagara Tamaki, Sadahiko Nishizawa, Yasuhiro Magata, Koichi Ishizu, Tatsuro Tsuchida, Norihiro Sadato, Junji Konishi, Akira Yokoyama, Ren Iwata, Tatsuo Ido

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    We have developed a new62Zn/62Cu positron generator, and applied it for PET imaging of perfusion and plasma volume in 5 normal subjects. The generator makes it possible by a simple procedure to obtain62Cu eluate and labeling compounds sufficiently every 40-60 minutes.62Cu labeled pyruvaldehyde bis(N4-methylthiosemicarbazone) copper II (62Cu-PTSM) was employed for cerebral and my ocardial perfusion imaging and62Cu labeled human serum albumin-dithiosemicarbazone (62Cu-HSA-DTS) was used for plasma pool imaging. The images of cerebral blood flow, cerebral plasma volume and myocardial perfusion were excellent. In addition, the analysis of tissue activity and blood activity demonstrated the microspheric character of62Cu-PTSM. Correction of arterial activity with the standard disappearance curve of62Cu-PTSM suggested the possibility of quantifying blood flow. The results of this study indicate the capability of the62Zn/62Cu generator for wide clinical use without an in-house cyclotron.

    Original languageEnglish
    Pages (from-to)81-87
    Number of pages7
    JournalAnnals of Nuclear Medicine
    Volume9
    Issue number2
    DOIs
    Publication statusPublished - 1995 Jun 1

    Keywords

    • Cu-HSA-DTS
    • Cu-PTSM
    • PET
    • perfusion tracer
    • plasma pool imaging

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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