Clinical application of18F-FUdR in glioma patients - PET study of nucleic acid metabolism

Motonobu Kameyama, Kiichi Ishiwata, Yuji Tsurumi, Jun Itoh, Kiyotaka Sato, Ryuichi Katakura, Takashi Yoshimoto, Jun Hatazawa, Masatoshi Itoh, Tatsuo Ido

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Positron emission tomography was used to investigate the metabolism of nucleic acids by18F-fluoro-2′-deoxyuridine (18F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 ± 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 ± 0.042 (p < 0.01). This PET-18F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism.

Original languageEnglish
Pages (from-to)53-61
Number of pages9
JournalJournal of Neuro-Oncology
Volume23
Issue number1
DOIs
Publication statusPublished - 1995 Feb 1

Keywords

  • F-fluoro-2′-deoxyuridine
  • PET
  • brain tumor
  • glioma
  • nucleic acid metabolism

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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