Clinical and physiological significance of abnormally prolonged central motor conduction time in HAM/TSP

Hiroshi Shimizu, Yusei Shiga, Kazuo Fujihara, Ayumu Ohnuma, Yasuto Itoyama

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We measured the central motor conduction time (CMCT), central sensory conduction time (CSCT), F wave and mean F wave/M wave amplitude ratio in patients with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) and controls. CMCTs in upper (U) and lower (L) limbs were significantly prolonged in HAM/TSP. L-CSCT was significantly prolonged in HAM/TSP, but U-CSCT in HAM/TSP and controls were not significantly different. CMCT and CSCT were significantly correlated in HAM/TSP. U-CMCT, but not L-CMCT, correlated with the clinical severity of HAM/TSP. Although F wave conduction velocity and its occurrence were normal in HAM/TSP, U- and L-mean F wave/M wave amplitude ratio tended to be higher in HAM/TSP, and the L-mean F wave/M wave amplitude ratio was significantly correlated with the L- and thoracic CMCT. These findings demonstrate that the prolongation of CMCT sensitively reflects the extension of the lesions and the disinhibition to the anterior horn cells in HAM/TSP.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalJournal of the neurological sciences
Volume185
Issue number1
DOIs
Publication statusPublished - 2001 Mar 15

Keywords

  • Central motor conduction time (CMCT)
  • Central sensory conduction time (CSCT)
  • F wave
  • Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
  • M wave
  • Motor evoked potential (MEP)
  • Somatosensory evoked potential (SEP)

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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