Clinical and MRI study of brain stem and cerebellar involvement in Japanese patients with multiple sclerosis

Ichiro Nakashima, Kazuo Fujihara, Naoshi Okita, Sadao Takase, Yasuto Itoyama

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

Objectives - To investigate the clinical and MRI features of brain stem and cerebellar lesions in Japanese patients with multiple sclerosis. Methods - A retrospective study of 66 consecutive Japanese patients with multiple sclerosis (42 women and 24 men) was done by reviewing the medical records and MRI films. Forty nine patients were diagnosed as having clinically definite multiple sclerosis and 17 patients as having clinically probable multiple sclerosis according to Poser's criteria. Prevalence rates of each brain stem and cerebellar manifestation and frequency and distribution of MRI lesions in these patients were studied. Results - Forty three patients (65%) had one or more infratentorial manifestations. Cranial nerves were clinically involved in 28 patients (42%), and most of the lesions were identified by MRI. Among them, manifestations of facial, trigeminal, and abducens nerves were relatively common. Cerebellar ataxia was found in 20 patients (30%). The MRI study showed that the lesions responsible for ataxia in these patients were mainly found in the cerebellar peduncles, but cerebellar hemispheric lesions were detected in only four patients (6.4%). Conclusion - The low frequency (6.4%) of the cerebellar MRI lesions in these patients is in sharp contrast with the figures reported for white patients with multiple sclerosis (50%-90%). Racial and genetic differences may have an influence on the susceptibility of each part of the CNS to demyelination in multiple sclerosis.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume67
Issue number2
DOIs
Publication statusPublished - 1999 Aug

Keywords

  • Cerebellum
  • Japanese
  • Magnetic resonance imaging
  • Multiple sclerosis

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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