We surveyed 35 patients who had been diagnosed with acute purulent otitis media (AOM) who were admitted to our department between 1995 and 1998. Penicillin-resistant Streptcoccus peumoniae (PRSP) was isolated from 15 patients (42%). The efficacy of cefotaxim (CTX) was satisfactory in all cases in which it was used. However, 4 patients in whom cefotium (CTM) was used showed no improvement, and 2 had recurrence of AOM. Ten of 15 patients who suffered from PRSP underwent immunologic examinations. The IgG2 level of one case was reduced; this patient also had MRSA infection. Levels of serum IgG2 antibody specific for S. peumoniae were low in 2 patients, one of whom had recurrent AOM, and the other had complications of mastoiditis. A decrease in plasma IgG2 levels might predict recurrent or severe AOM. Immunological studies with reagents such as specific antibody for S. peumoniae might be useful for prognostic estimation of AOM.
|Journal||Journal of Tokyo Women's Medical College|
|Issue number||SUPPL. JUNE|
|Publication status||Published - 2000 Jan 1|
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