TY - JOUR
T1 - Clinical and histological features of lupus nephritis in Japan
T2 - A cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR)
AU - Hiromura, Keiju
AU - Ikeuchi, Hidekazu
AU - Kayakabe, Ken
AU - Sugiyama, Hitoshi
AU - Nagata, Michio
AU - Sato, Hiroshi
AU - Yokoyama, Hitoshi
AU - Nojima, Yoshihisa
N1 - Funding Information:
This study was supported by a grant-in-aid from the Research Group on Progressive Renal Disease from the Ministry of Health, Labor and Welfare, Japan. The authors are grateful for the help and support from the J-RBR committee and all of the colleagues who participated in the J-RBR governed by Japanese Society of Nephrology. The lists of investigators and hospitals were shown in Supplementary Appendix.
Publisher Copyright:
© 2016 Asian Pacific Society of Nephrology
PY - 2017/11
Y1 - 2017/11
N2 - Aim: The clinical and histological features of lupus nephritis (LN) are highly variable, depending on race and ethnicity. The Japan Renal Biopsy Registry (J-RBR) is a nationwide registry of renal biopsies. Here, we report a cross-sectional analysis of Japanese LN using the J-RBR database. Methods: Out of 18 463 patients registered in the J-RBR, 331 LN patients, who received renal biopsy for the first time, were extracted and their clinical features were analyzed according to the ISN/RPS 2003 classification. Results: The median age of the 331 LN patients was 37 years (women, 81.3%). The frequencies of each of the ISN/RPS Classes were as follows: I, 1.2%; II, 7.9%; III (±V), 25.1%; IV-S (±V), 13.0%; IV-G (±V), 31.1%; V, 20.8%; and VI, 0.9%. The level of proteinuria and the prevalence of nephrotic syndrome were highest for Class IV-G (±V). When Classes I, II, and VI were excluded from the analysis, Class IV-G (±V) was significantly associated with a lower eGFR and severer haematuria than the other classes. Conclusion: This nationwide study revealed that Class IV-G (±V) was the most prevalent form of LN in Japan and was associated with a severe clinical renal presentation.
AB - Aim: The clinical and histological features of lupus nephritis (LN) are highly variable, depending on race and ethnicity. The Japan Renal Biopsy Registry (J-RBR) is a nationwide registry of renal biopsies. Here, we report a cross-sectional analysis of Japanese LN using the J-RBR database. Methods: Out of 18 463 patients registered in the J-RBR, 331 LN patients, who received renal biopsy for the first time, were extracted and their clinical features were analyzed according to the ISN/RPS 2003 classification. Results: The median age of the 331 LN patients was 37 years (women, 81.3%). The frequencies of each of the ISN/RPS Classes were as follows: I, 1.2%; II, 7.9%; III (±V), 25.1%; IV-S (±V), 13.0%; IV-G (±V), 31.1%; V, 20.8%; and VI, 0.9%. The level of proteinuria and the prevalence of nephrotic syndrome were highest for Class IV-G (±V). When Classes I, II, and VI were excluded from the analysis, Class IV-G (±V) was significantly associated with a lower eGFR and severer haematuria than the other classes. Conclusion: This nationwide study revealed that Class IV-G (±V) was the most prevalent form of LN in Japan and was associated with a severe clinical renal presentation.
KW - ISN/RPS classification
KW - lupus nephritis
KW - renal biopsy registry
KW - systemic lupus erythematosus
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U2 - 10.1111/nep.12863
DO - 10.1111/nep.12863
M3 - Article
C2 - 27461874
AN - SCOPUS:85031494371
SN - 1320-5358
VL - 22
SP - 885
EP - 891
JO - Nephrology
JF - Nephrology
IS - 11
ER -