Clinical and bacteriological influence of diabetes mellitus on deep neck infection: Systematic review and meta-analysis

Hiroshi Hidaka, Takuhiro Yamaguchi, Jun Hasegawa, Hisakazu Yano, Risako Kakuta, Daiki Ozawa, Kazuhiro Nomura, Yukio Katori

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background Diabetes mellitus has been recognized as the most common systemic disease associated with deep neck infection. We report the first systematic review and meta-analysis of the influence of diabetes on clinical and bacteriological characteristics of deep neck infection. Methods Articles were retrieved from PubMed, EMBASE, and the Japan Medical Abstracts Society database. A critical review of 227 studies identified 20 studies eligible for quantitative synthesis. Results Diabetes was associated with higher prevalences of multispace spread of infection, complications, and failure to identify pathogenesis, with risk ratios (RRs) of 1.96, 2.42, and 1.29, respectively. Bacteriologically, patients with diabetes showed a higher prevalence of culture identification of Klebsiella pneumoniae (RR, 3.28), and lower prevalences of Streptococcus spp. (RR, 0.57) and anaerobes (RR, 0.54). Conclusion Deep neck infection with diabetes differs from that without in several clinical aspects. Again, bacteriological differences imply that diabetic infections might be populated by different bacterial flora.

Original languageEnglish
Pages (from-to)1536-1546
Number of pages11
JournalHead and Neck
Volume37
Issue number10
DOIs
Publication statusPublished - 2015 Oct 1

Keywords

  • complications
  • deep neck infections
  • diabetes mellitus
  • meta-analysis
  • systematic review

ASJC Scopus subject areas

  • Otorhinolaryngology

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