Clinical and bacteriological characteristics of Helicobacter cinaedi infection

Yoshiaki Kawamura, Junko Tomida, Yuji Morita, Shigemoto Fujii, Tatsuya Okamoto, Takaaki Akaike

Research output: Contribution to journalReview articlepeer-review

60 Citations (Scopus)

Abstract

Helicobacter cinaedi was first isolated from rectal cultures from homosexual men in 1984. In the 1980s to mid 1990s, the microorganism was mainly isolated from samples from homosexual men or immunocompromised patients; however, during the last two decades, H. cinaedi has been isolated from immunocompromised and from immunocompetent individuals worldwide. In Japan, the isolation of this microorganism was first reported in 2003. Since then, many cases have been reported in hospitals across the country. Despite many reports, the etiological properties and pathogenicity of H. cinaedi remain elusive; however, we are increasingly able to recognize some of the features and the clinical relevance of infection. In particular, a long incubation period is essential for detection in an automatic blood culture system and many of the recent isolates are resistant to both macrolides and quinolones. Furthermore, there is an association between infection and severe or chronic illnesses, such as meningitis or arteriosclerosis, in addition to mild diseases such as fever, abdominal pain, gastroenteritis, proctitis, diarrhea, erysipelas, cellulitis, arthritis, and bacteremia. In this review, we introduce the current knowledge and our latest findings relating to H. cinaedi.

Original languageEnglish
Pages (from-to)517-526
Number of pages10
JournalJournal of Infection and Chemotherapy
Volume20
Issue number9
DOIs
Publication statusPublished - 2014 Sep

Keywords

  • Arteriosclerosis
  • Emerging infection
  • Helicobacter
  • Nosocomial infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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