Click-based synthesis and proteomic profiling of lipstatin analogues

Mun H. Ngai, Peng Yu Yang, Kai Liu, Yuan Shen, Markus R. Wenk, Shao Q. Yao, Martin J. Lear

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.

Original languageEnglish
Pages (from-to)8335-8337
Number of pages3
JournalChemical Communications
Volume46
Issue number44
DOIs
Publication statusPublished - 2010 Nov 28

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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