Clerodane diterpenoids and flavonoids with NGF-potentiating activity from the aerial parts of Baccharis gaudichaudiana

Yuanqiang Guo, Yushan Li, Jing Xu, Ning Li, Tohru Yamakuni, Yasushi Ohizumi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

A new clerodane diterpene, 15-hydroxy-16-acetoxy-ent-clerod-3-en-18-oic acid (1), together with three known clerodane diterpenes (2-4) and three known flavones (5-7), were isolated from the aerial parts of Baccharis gaudichaudiana. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2, 3, and 5 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

Original languageEnglish
Pages (from-to)1532-1534
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume55
Issue number10
DOIs
Publication statusPublished - 2007 Oct

Keywords

  • Baccharis gaudichaudiana
  • Clerodane diterpene
  • Flavone
  • Nerve growth factor (NGF)-potentiating activity

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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