Clear cell variant of calcifying epithelial odontogenic tumor (CEOT) in the maxilla: Report of a case with immunohistochemical and ultrastructural investigations

Hiroyuki Kumamoto, Ikuro Sato, Hiroo Tateno, Junkichi Yokoyama, Tetsu Takahashi, Kiyoshi Ooya

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

A rare case of clear cell variant of calcifying epithelial odontogenic tumor is presented with immunohistochemieal and ultrastructural investigations. A 14-year-old Japanese girl was admitted with a complaint of swelling in the right posterior maxilla. Radiological examination showed a well-circumscribed radiolucent lesion located close to the impacted third molar. After only a partial tumor excision, the tumor recurred 13 years later. It appeared radiologically as an irregular radiodensity, and a subtotal maxillectomy was performed. Histological examination showed sheets and/or strands composed almost entirely of clear vacuolated epithelial cells in a stroma containing intercellular amyloid-like material and calcification. Histochemical and ultrastructural analysis detected cytoplasmic glycogen granules in the clear cells, and positive immunoreactivities for cytokeratins 8, 13 and 19; filaggrin and anti-ameloblastoma antibodies suggested an odontogenic epithelial origin.

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalJournal of Oral Pathology and Medicine
Volume28
Issue number4
DOIs
Publication statusPublished - 1999 Apr

Keywords

  • Calcifying epithelial odontogenic tumor (CEOT)
  • Clear cell
  • Immunohistochemistry
  • Maxilla
  • Odontogenic tumor
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

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