TY - JOUR
T1 - Clear cell carcinoma of the nasal cavity
T2 - A case report from histopathological viewpoint
AU - Imai, Takayuki
AU - Satoh, Ikuro
AU - Matsumoto, Ko
AU - Ito, Shigemi
AU - Asada, Yukinori
AU - Kato, Kengo
AU - Koshiba, Yasutoshi
AU - Saijo, Shigeru
AU - Matsuura, Kazuto
N1 - Publisher Copyright:
© 2015.Published by Elsevier Ireland Ltd.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - We report an extremely rare case of primary clear cell carcinoma (CCC), not otherwise specified (NOS) of the nasal cavity. An 80-year-old woman was referred to our hospital with left nasal obstruction caused by a nasal cavity tumor. The tumor was resected completely with lateral rhinotomy approach. Histopathological examination revealed CCC. CCC metastasis from renal cell carcinoma (RCC), which is at the top of differential diagnosis, was ruled out by the absence of renal tumor at computed tomography (CT). Also, immunohistochemical results of the specimen with vimentin negative and CK7 focally positive excluded the possibility of RCC metastasis. The patient is free from recurrence 1 year after the surgery, and there is no evidence of RCC. In this report histopathological characteristics, especially immunohistochemical properties of primary CCC, NOS of the nasal cavity are presented together with some clinical features of this rare tumor. Also, we refer to histopathogenesis of primary CCC of nasal cavity in relation to myoepithelial carcinoma. Histopathological discussion is further extended to include other CCC and CCC-resembling histologies to confirm the uniqueness of the present case.
AB - We report an extremely rare case of primary clear cell carcinoma (CCC), not otherwise specified (NOS) of the nasal cavity. An 80-year-old woman was referred to our hospital with left nasal obstruction caused by a nasal cavity tumor. The tumor was resected completely with lateral rhinotomy approach. Histopathological examination revealed CCC. CCC metastasis from renal cell carcinoma (RCC), which is at the top of differential diagnosis, was ruled out by the absence of renal tumor at computed tomography (CT). Also, immunohistochemical results of the specimen with vimentin negative and CK7 focally positive excluded the possibility of RCC metastasis. The patient is free from recurrence 1 year after the surgery, and there is no evidence of RCC. In this report histopathological characteristics, especially immunohistochemical properties of primary CCC, NOS of the nasal cavity are presented together with some clinical features of this rare tumor. Also, we refer to histopathogenesis of primary CCC of nasal cavity in relation to myoepithelial carcinoma. Histopathological discussion is further extended to include other CCC and CCC-resembling histologies to confirm the uniqueness of the present case.
KW - Clear cell carcinoma NOS
KW - Hyalinizing clear cell carcinoma
KW - Myoepithelial carcinoma
KW - Nasal cavity
KW - Renal cell carcinoma
KW - Sinonasal renal cell-like adenocarcinoma
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U2 - 10.1016/j.anl.2015.06.002
DO - 10.1016/j.anl.2015.06.002
M3 - Article
C2 - 26140982
AN - SCOPUS:84958039125
VL - 43
SP - 108
EP - 111
JO - Auris Nasus Larynx
JF - Auris Nasus Larynx
SN - 0385-8146
IS - 1
ER -