Circulating oxidized LDL: A biomarker and a pathogenic factor

Yasushi Ishigaki, Yoshitomo Oka, Hideki Katagiri

Research output: Contribution to journalReview articlepeer-review

117 Citations (Scopus)

Abstract

Purpose of review: Oxidized LDL (oxLDL) contributes to many atherogenic steps in the vascular wall, but the significance of oxLDL in circulating blood remains unclear. Recent progress in procedures for measuring both human and murine oxLDL has provided growing evidence of the importance of circulating oxLDL. Recent findings: Circulating oxLDL is elevated in patients with advanced atherosclerosis, such as coronary heart disease and ischemic stroke, and also reflects early atherosclerotic changes and metabolic disorders including diabetes and obesity. In-vitro exposure to oxLDL increased mononuclear cell nuclear factor-KB activity, suggesting a pathogenic role of circulating oxLDL in exacerbation of oxidative stress. In addition, adenoviral administration of secreted scavenger receptor-A1, which functions as a decoy, suppresses foam cell formation in LDL receptor-deficient mice via a blockade of modified LDL incorporation into macrophages. Furthermore, when lectin-like oxLDL receptor-1 was ectopically expressed in the liver, circulating oxLDL was reduced, resulting in complete prevention of atherosclerotic progression in apolipoprotein E-deficient mice. Thus, circulating oxLDL impacts atherogenic formation. Summary: The roles of circulating oxLDL in atherosclerotic pathogenesis are now attracting considerable attention. OxLDL removal from circulating blood is a promising therapeutic strategy against atherosclerosis

Original languageEnglish
Pages (from-to)363-369
Number of pages7
JournalCurrent Opinion in Lipidology
Volume20
Issue number5
DOIs
Publication statusPublished - 2009 Oct
Externally publishedYes

Keywords

  • Atherosclerosis
  • Inflammation
  • Oxidative stress
  • Oxidized LDL
  • Scavenger receptors

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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