Circular dichroism thermal lens microscope for sensitive and selective detection of chiral samples on microchip

Kazuma Mawatari, Masayo Yamauchi, Akihide Hibara, Manabu Tokeshi, Takehiko Kitamori

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Thermal lens microscope (TLM) is a kind of absorption spectrometry with a sensitivity of single molecules in fL detection volume. In this paper, we report a newly functionalized TLM for selective and sensitive detection of chiral samples. We developed a circular dichroism (CD) thermal lens microscope by light phase modulation. We verified the basic principle and achieved two orders higher sensitivity than CD spectrometer.

Original languageEnglish
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages1035-1037
Number of pages3
ISBN (Print)0974361119, 9780974361116
Publication statusPublished - 2005 Jan 1
Externally publishedYes
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: 2005 Oct 92005 Oct 13

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period05/10/905/10/13

Keywords

  • Circular dichroism
  • Non-fluorescent molecules
  • Thermal lens microscope

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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