Cinatrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958

Takahiro Ishii, Kenichi Nonaka, Akihiro Sugawara, Masato Iwatsuki, Rokuro Masuma, Tomoyasu Hirose, Toshiaki Sunazuka, Satoshi Omura, Kazuro Shiomi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Two new hydroxycitric acid lactone derivatives named cinatrins D (1) and E (2), and a new γ-lactam, virgaricin B (3), along with a known similar compound, virgaricin (4), were isolated from a fermentation broth of the fungus Virgaria boninensis FKI-4958. The absolute stereo structures of the new compounds were established by a combination of spectroscopic methods and chemical modifications. All three newly discovered compounds possessed weak antibacterial activity.

Original languageEnglish
Pages (from-to)633-637
Number of pages5
JournalJournal of Antibiotics
Volume68
Issue number10
DOIs
Publication statusPublished - 2015 Oct 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Ishii, T., Nonaka, K., Sugawara, A., Iwatsuki, M., Masuma, R., Hirose, T., Sunazuka, T., Omura, S., & Shiomi, K. (2015). Cinatrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958. Journal of Antibiotics, 68(10), 633-637. https://doi.org/10.1038/ja.2015.45