Cinatrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958

Takahiro Ishii; Kenichi Nonaka; Akihiro Sugawara; Masato Iwatsuki; Rokuro Masuma; Tomoyasu Hirose; Toshiaki Sunazuka; Satoshi Omura; Kazuro Shiomi

doi:10.1038/ja.2015.45

Cinatrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958

Takahiro Ishii, Kenichi Nonaka, Akihiro Sugawara, Masato Iwatsuki, Rokuro Masuma, Tomoyasu Hirose, Toshiaki Sunazuka, Satoshi Omura, Kazuro Shiomi

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Two new hydroxycitric acid lactone derivatives named cinatrins D (1) and E (2), and a new γ-lactam, virgaricin B (3), along with a known similar compound, virgaricin (4), were isolated from a fermentation broth of the fungus Virgaria boninensis FKI-4958. The absolute stereo structures of the new compounds were established by a combination of spectroscopic methods and chemical modifications. All three newly discovered compounds possessed weak antibacterial activity.

Original language	English
Pages (from-to)	633-637
Number of pages	5
Journal	Journal of Antibiotics
Volume	68
Issue number	10
DOIs	https://doi.org/10.1038/ja.2015.45
Publication status	Published - 2015 Oct 1
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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Cinatrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958. / Ishii, Takahiro; Nonaka, Kenichi; Sugawara, Akihiro; Iwatsuki, Masato; Masuma, Rokuro; Hirose, Tomoyasu; Sunazuka, Toshiaki; Omura, Satoshi; Shiomi, Kazuro.

In: Journal of Antibiotics, Vol. 68, No. 10, 01.10.2015, p. 633-637.

Research output: Contribution to journal › Article › peer-review

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AU - Iwatsuki, Masato

AU - Masuma, Rokuro

AU - Hirose, Tomoyasu

AU - Sunazuka, Toshiaki

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Cinatrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958

Abstract

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