Chrymutasins: Novel-aglycone antitumor antibiotics from a mutant of streptomyces chartreusis. II. Characterization and structural elucidation

Hideaki Uchida, Yasukazu Nakakita, Nobuyasu Enoki, Naoki Abe, Takehiko Nakamura, Masanobu Munekata

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Chrymutasins A, B and C are glycosidic antibiotics produced by a mutant of the chartreusin producer-organism Streptomyces chartreusis. We report here the structure elucidation of these compounds. The sugar moieties involved were determined by comparison with the related chartreusins. The structure of the aglycone, the same in all three compounds, was elucidated by NMR, incorporation studies of labeled compounds and synthesis of derivatives. The chrymutasin aglycone differs from that of chartreusin by a single carbon and an amino group.

Original languageEnglish
Pages (from-to)655-667
Number of pages13
Journalthe journal of antibiotics
Volume47
Issue number6
DOIs
Publication statusPublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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