Chrymutasins: Novel-aglycone antitumor antibiotics from a mutant of streptomyces chartreusis. I. Taxonomy, mutation, fermentation, isolation and biological activities

Hideaki Uchida, Yasukazu Nakakita, Nobuyasu Enoki, Naoki Abe, Takehiko Nakamura, Masanobu Munekata

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Three novel antibiotics, named chrymutasins A, B and C, were isolated from the fermentation products of a mutant strain obtained by NTG (N-methyl-N′-nitro-N-nitrosoguanidine) treatment. The mutant strain produced the chrymutasins, which differed in the aglycone moiety from chartreusin, and related compounds. The production of these compounds needed a characteristically long fermentation period. The antitumor activity of chrymutasin A is better in vivo than that of chartreusin, the cytotoxic activity against cell lines in vitro is equivalent, and the antimicrobial spectrum is narrower.

Original languageEnglish
Pages (from-to)648-654
Number of pages7
Journalthe journal of antibiotics
Volume47
Issue number6
DOIs
Publication statusPublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint Dive into the research topics of 'Chrymutasins: Novel-aglycone antitumor antibiotics from a mutant of streptomyces chartreusis. I. Taxonomy, mutation, fermentation, isolation and biological activities'. Together they form a unique fingerprint.

Cite this