Chronic neutrophilic leukemia with acute myeloblastic transformation

Kensaku Katsuki; Kenji Shinohara; Koumei Takeda; Kouichi Ariyoshi; Tetsuya Yamada; Naoko Kameda; Toru Takahashi; Ryohei Nawata; Shoichiro Shibata; Yoshinobu Asano; Seiichi Okamura

doi:10.1093/jjco/hyd090

Chronic neutrophilic leukemia with acute myeloblastic transformation

Kensaku Katsuki, Kenji Shinohara, Koumei Takeda, Kouichi Ariyoshi, Tetsuya Yamada, Naoko Kameda, Toru Takahashi, Ryohei Nawata, Shoichiro Shibata, Yoshinobu Asano, Seiichi Okamura

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We report a rare case of chronic neutrophilic leukemia (CNL) which terminated in acute myeloblastic transformation 3 years after the onset of the disease. The increased leukocytes were mainly neutrophils at various maturational stages until 1 month before transformation without dysplastic hematopoietic cells or other myeloproliferative disorders. Repeated analyses for the Philadelphia chromosome (Ph1), rearrangement of the BCR gene or chimeric BCR/ABL mRNA, major, minor and μ, were negative. Genomic analysis of granulocyte colony-stimulating factor (G-CSF) receptor did not reveal any abnormality. The clinical manifestations were characterized by hyperleukocyte syndrome with respiratory distress and ischemic legs with gangrene.

Original language	English
Pages (from-to)	362-365
Number of pages	4
Journal	Japanese journal of clinical oncology
Volume	30
Issue number	8
DOIs	https://doi.org/10.1093/jjco/hyd090
Publication status	Published - 2000
Externally published	Yes

Keywords

Acute myeloblastic transformation
BCR/ABL
Chronic neutrophilic leukemia
G-CSF receptor
Hyperleukocyte syndrome
Ph1

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/jjco/hyd090

Cite this

Chronic neutrophilic leukemia with acute myeloblastic transformation. / Katsuki, Kensaku; Shinohara, Kenji; Takeda, Koumei; Ariyoshi, Kouichi; Yamada, Tetsuya; Kameda, Naoko; Takahashi, Toru; Nawata, Ryohei; Shibata, Shoichiro; Asano, Yoshinobu; Okamura, Seiichi.

In: Japanese journal of clinical oncology, Vol. 30, No. 8, 2000, p. 362-365.

Research output: Contribution to journal › Article › peer-review

@article{3f4598f171c54e979d61f91f54739534,

title = "Chronic neutrophilic leukemia with acute myeloblastic transformation",

abstract = "We report a rare case of chronic neutrophilic leukemia (CNL) which terminated in acute myeloblastic transformation 3 years after the onset of the disease. The increased leukocytes were mainly neutrophils at various maturational stages until 1 month before transformation without dysplastic hematopoietic cells or other myeloproliferative disorders. Repeated analyses for the Philadelphia chromosome (Ph1), rearrangement of the BCR gene or chimeric BCR/ABL mRNA, major, minor and μ, were negative. Genomic analysis of granulocyte colony-stimulating factor (G-CSF) receptor did not reveal any abnormality. The clinical manifestations were characterized by hyperleukocyte syndrome with respiratory distress and ischemic legs with gangrene.",

keywords = "Acute myeloblastic transformation, BCR/ABL, Chronic neutrophilic leukemia, G-CSF receptor, Hyperleukocyte syndrome, Ph1",

author = "Kensaku Katsuki and Kenji Shinohara and Koumei Takeda and Kouichi Ariyoshi and Tetsuya Yamada and Naoko Kameda and Toru Takahashi and Ryohei Nawata and Shoichiro Shibata and Yoshinobu Asano and Seiichi Okamura",

year = "2000",

doi = "10.1093/jjco/hyd090",

language = "English",

volume = "30",

pages = "362--365",

journal = "Japanese Journal of Clinical Oncology",

issn = "0368-2811",

publisher = "Oxford University Press",

number = "8",

}

TY - JOUR

T1 - Chronic neutrophilic leukemia with acute myeloblastic transformation

AU - Katsuki, Kensaku

AU - Shinohara, Kenji

AU - Takeda, Koumei

AU - Ariyoshi, Kouichi

AU - Yamada, Tetsuya

AU - Kameda, Naoko

AU - Takahashi, Toru

AU - Nawata, Ryohei

AU - Shibata, Shoichiro

AU - Asano, Yoshinobu

AU - Okamura, Seiichi

PY - 2000

Y1 - 2000

N2 - We report a rare case of chronic neutrophilic leukemia (CNL) which terminated in acute myeloblastic transformation 3 years after the onset of the disease. The increased leukocytes were mainly neutrophils at various maturational stages until 1 month before transformation without dysplastic hematopoietic cells or other myeloproliferative disorders. Repeated analyses for the Philadelphia chromosome (Ph1), rearrangement of the BCR gene or chimeric BCR/ABL mRNA, major, minor and μ, were negative. Genomic analysis of granulocyte colony-stimulating factor (G-CSF) receptor did not reveal any abnormality. The clinical manifestations were characterized by hyperleukocyte syndrome with respiratory distress and ischemic legs with gangrene.

AB - We report a rare case of chronic neutrophilic leukemia (CNL) which terminated in acute myeloblastic transformation 3 years after the onset of the disease. The increased leukocytes were mainly neutrophils at various maturational stages until 1 month before transformation without dysplastic hematopoietic cells or other myeloproliferative disorders. Repeated analyses for the Philadelphia chromosome (Ph1), rearrangement of the BCR gene or chimeric BCR/ABL mRNA, major, minor and μ, were negative. Genomic analysis of granulocyte colony-stimulating factor (G-CSF) receptor did not reveal any abnormality. The clinical manifestations were characterized by hyperleukocyte syndrome with respiratory distress and ischemic legs with gangrene.

KW - Acute myeloblastic transformation

KW - BCR/ABL

KW - Chronic neutrophilic leukemia

KW - G-CSF receptor

KW - Hyperleukocyte syndrome

KW - Ph1

UR - http://www.scopus.com/inward/record.url?scp=0033762423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033762423&partnerID=8YFLogxK

U2 - 10.1093/jjco/hyd090

DO - 10.1093/jjco/hyd090

M3 - Article

C2 - 11059343

AN - SCOPUS:0033762423

VL - 30

SP - 362

EP - 365

JO - Japanese Journal of Clinical Oncology

JF - Japanese Journal of Clinical Oncology

SN - 0368-2811

IS - 8

ER -

Chronic neutrophilic leukemia with acute myeloblastic transformation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this