Abstract
We report a rare case of chronic neutrophilic leukemia (CNL) which terminated in acute myeloblastic transformation 3 years after the onset of the disease. The increased leukocytes were mainly neutrophils at various maturational stages until 1 month before transformation without dysplastic hematopoietic cells or other myeloproliferative disorders. Repeated analyses for the Philadelphia chromosome (Ph1), rearrangement of the BCR gene or chimeric BCR/ABL mRNA, major, minor and μ, were negative. Genomic analysis of granulocyte colony-stimulating factor (G-CSF) receptor did not reveal any abnormality. The clinical manifestations were characterized by hyperleukocyte syndrome with respiratory distress and ischemic legs with gangrene.
Original language | English |
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Pages (from-to) | 362-365 |
Number of pages | 4 |
Journal | Japanese journal of clinical oncology |
Volume | 30 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2000 |
Keywords
- Acute myeloblastic transformation
- BCR/ABL
- Chronic neutrophilic leukemia
- G-CSF receptor
- Hyperleukocyte syndrome
- Ph1
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research