Chronic neutrophilic leukemia with acute myeloblastic transformation

Kensaku Katsuki, Kenji Shinohara, Koumei Takeda, Kouichi Ariyoshi, Tetsuya Yamada, Naoko Kameda, Toru Takahashi, Ryohei Nawata, Shoichiro Shibata, Yoshinobu Asano, Seiichi Okamura

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


We report a rare case of chronic neutrophilic leukemia (CNL) which terminated in acute myeloblastic transformation 3 years after the onset of the disease. The increased leukocytes were mainly neutrophils at various maturational stages until 1 month before transformation without dysplastic hematopoietic cells or other myeloproliferative disorders. Repeated analyses for the Philadelphia chromosome (Ph1), rearrangement of the BCR gene or chimeric BCR/ABL mRNA, major, minor and μ, were negative. Genomic analysis of granulocyte colony-stimulating factor (G-CSF) receptor did not reveal any abnormality. The clinical manifestations were characterized by hyperleukocyte syndrome with respiratory distress and ischemic legs with gangrene.

Original languageEnglish
Pages (from-to)362-365
Number of pages4
JournalJapanese journal of clinical oncology
Issue number8
Publication statusPublished - 2000
Externally publishedYes


  • Acute myeloblastic transformation
  • Chronic neutrophilic leukemia
  • G-CSF receptor
  • Hyperleukocyte syndrome
  • Ph1

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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