Chronic neutrophilic leukemia with acute myeloblastic transformation

Kensaku Katsuki; Kenji Shinohara; Koumei Takeda; Kouichi Ariyoshi; Tetsuya Yamada; Naoko Kameda; Toru Takahashi; Ryohei Nawata; Shoichiro Shibata; Yoshinobu Asano; Seiichi Okamura

doi:10.1093/jjco/hyd090

Chronic neutrophilic leukemia with acute myeloblastic transformation

Kensaku Katsuki, Kenji Shinohara, Koumei Takeda, Kouichi Ariyoshi, Tetsuya Yamada, Naoko Kameda, Toru Takahashi, Ryohei Nawata, Shoichiro Shibata, Yoshinobu Asano, Seiichi Okamura

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We report a rare case of chronic neutrophilic leukemia (CNL) which terminated in acute myeloblastic transformation 3 years after the onset of the disease. The increased leukocytes were mainly neutrophils at various maturational stages until 1 month before transformation without dysplastic hematopoietic cells or other myeloproliferative disorders. Repeated analyses for the Philadelphia chromosome (Ph1), rearrangement of the BCR gene or chimeric BCR/ABL mRNA, major, minor and μ, were negative. Genomic analysis of granulocyte colony-stimulating factor (G-CSF) receptor did not reveal any abnormality. The clinical manifestations were characterized by hyperleukocyte syndrome with respiratory distress and ischemic legs with gangrene.

Original language	English
Pages (from-to)	362-365
Number of pages	4
Journal	Japanese journal of clinical oncology
Volume	30
Issue number	8
DOIs	https://doi.org/10.1093/jjco/hyd090
Publication status	Published - 2000

Keywords

Acute myeloblastic transformation
BCR/ABL
Chronic neutrophilic leukemia
G-CSF receptor
Hyperleukocyte syndrome
Ph1

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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Chronic neutrophilic leukemia with acute myeloblastic transformation. / Katsuki, Kensaku; Shinohara, Kenji; Takeda, Koumei; Ariyoshi, Kouichi; Yamada, Tetsuya; Kameda, Naoko; Takahashi, Toru; Nawata, Ryohei; Shibata, Shoichiro; Asano, Yoshinobu; Okamura, Seiichi.

In: Japanese journal of clinical oncology, Vol. 30, No. 8, 2000, p. 362-365.

Research output: Contribution to journal › Article › peer-review

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AU - Kameda, Naoko

AU - Takahashi, Toru

AU - Nawata, Ryohei

AU - Shibata, Shoichiro

AU - Asano, Yoshinobu

AU - Okamura, Seiichi

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