Chronic Granulomatous Disease with Neutrophil Membrane Cytochrome B Deficiency: Demonstration by Immunochemical Staining with Monoclonal Antibody

Naoko Minegishi; Ken Suzaki; Masahiko Terasawa; Masayoshi Minegishi; Shigeru Tsuchiya; Tasuke Konno; Michio Nakamura

doi:10.1620/tjem.154.143

Chronic Granulomatous Disease with Neutrophil Membrane Cytochrome B Deficiency: Demonstration by Immunochemical Staining with Monoclonal Antibody

Naoko Minegishi, Ken Suzaki, Masahiko Terasawa, Masayoshi Minegishi, Shigeru Tsuchiya, Tasuke Konno, Michio Nakamura

Tohoku Medical Megabank Organization (ToMMo)

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Cytochrome b deficicency in the peripheral granulocytes of two male patients with chronic granulomatous disease was demonstrated by an immunocytochemical assay using a monoclonal antibody, 7D5, against human neutrophil cytochrome b. A mosaic of cytochrome b positive and negative neutrophils, indicating a carrier state in an X-linked trait, was found in the mother of patient 1 but not in the mother of patient 2.

Original language	English
Pages (from-to)	143-148
Number of pages	6
Journal	the tohoku journal of experimental medicine
Volume	154
Issue number	2
DOIs	https://doi.org/10.1620/tjem.154.143
Publication status	Published - 1988

Keywords

chronic granuromatous disease
cytochrome b
leukocyte

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1620/tjem.154.143

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Chronic Granulomatous Disease with Neutrophil Membrane Cytochrome B Deficiency : Demonstration by Immunochemical Staining with Monoclonal Antibody. / Minegishi, Naoko; Suzaki, Ken; Terasawa, Masahiko; Minegishi, Masayoshi; Tsuchiya, Shigeru; Konno, Tasuke; Nakamura, Michio.

In: the tohoku journal of experimental medicine, Vol. 154, No. 2, 1988, p. 143-148.

Research output: Contribution to journal › Article › peer-review

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AU - Tsuchiya, Shigeru

AU - Konno, Tasuke

AU - Nakamura, Michio

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