Chronic Granulomatous Disease with Neutrophil Membrane Cytochrome B Deficiency: Demonstration by Immunochemical Staining with Monoclonal Antibody

Naoko Minegishi, Ken Suzaki, Masahiko Terasawa, Masayoshi Minegishi, Shigeru Tsuchiya, Tasuke Konno, Michio Nakamura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Cytochrome b deficicency in the peripheral granulocytes of two male patients with chronic granulomatous disease was demonstrated by an immunocytochemical assay using a monoclonal antibody, 7D5, against human neutrophil cytochrome b. A mosaic of cytochrome b positive and negative neutrophils, indicating a carrier state in an X-linked trait, was found in the mother of patient 1 but not in the mother of patient 2.

Original languageEnglish
Pages (from-to)143-148
Number of pages6
Journalthe tohoku journal of experimental medicine
Volume154
Issue number2
DOIs
Publication statusPublished - 1988

Keywords

  • chronic granuromatous disease
  • cytochrome b
  • leukocyte

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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