Chronic glomerulonephritis associated with IgG subclass deficiency

Koichi Kamei, Atsuko Nakagawa, Yasufumi Otsuka, Makiko Nakayama, Shinichi Kobayashi, Kentaro Matsuoka, Kazumoto Iijima

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    We experienced two patients with IgG subclass deficiency who suffered from chronic glomerulonephritis (GN). Patient 1 was a 17-year-old girl with IgG subclass deficiency (combined deficiency of IgG2 and IgG4). Renal biopsy was performed when she was aged 16 years, and she was diagnosed with membranoproliferative GN. Patient 2 was a 16-year-old girl with IgG subclass deficiency (combined deficiency of IgG2, IgG3, and IgG4). Renal biopsy was performed when she was aged 15 years, and she was diagnosed with membranous nephropathy. We examined the glomerular deposition patterns of their IgG subclasses. Furthermore, we compared their clinical and laboratory findings with those of three patients with IgG subclass deficiency without GN. Patients with GN suffered infections more frequently than those without GN. The serum levels of IgG (especially IgG1) and IgM were higher in patients with GN than in those without GN. In patient 1 IgG1 and IgG3 were deposited in a mesangiocapillary pattern, but, in patient 2, only IgG1 was deposited in a capillary pattern. Thus, the different patterns of IgG subclass deficiency between the two patients may be responsible for their different glomerular pathologies. To the best of our knowledge, this is the first report of chronic GN in patients with IgG subclass deficiency.

    Original languageEnglish
    Pages (from-to)1229-1234
    Number of pages6
    JournalPediatric Nephrology
    Volume22
    Issue number8
    DOIs
    Publication statusPublished - 2007 Aug 1

    Keywords

    • Chronic glomerulonephritis
    • IgG subclass deficiency
    • Infection
    • Membranoproliferative glomerulonephritis
    • Membranous nephropathy

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Nephrology

    Fingerprint Dive into the research topics of 'Chronic glomerulonephritis associated with IgG subclass deficiency'. Together they form a unique fingerprint.

  • Cite this

    Kamei, K., Nakagawa, A., Otsuka, Y., Nakayama, M., Kobayashi, S., Matsuoka, K., & Iijima, K. (2007). Chronic glomerulonephritis associated with IgG subclass deficiency. Pediatric Nephrology, 22(8), 1229-1234. https://doi.org/10.1007/s00467-007-0474-6