Chronic effects of synthetic endothelin on blood pressure and sodium excretion in rats

Minoru Yasujima, Keishi Abe, Masayuki Kanazazva, Kazunori Yoshida, Makito Sato, Kazuhisa Takeuchi, Kazuo Tsunoda, Kei Kudo, Masahiro Kohzuki, Ken Omata, Kaoru Yoshinaga

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Continuous infusion of endothelin at a rate of 60 μg/kg/day into the jugular vein of rats via osmotic minipumps induced a significant increase in systolic blood pressure, but did not induce any significant changes in urine volume and urinary sodium excretion, compared to those in vehicle-infused rats. When 6 mg/kg/day of benidipine, a newly developed calcium channel blocker, was administered simultaneously with 60 μg/kg/day of endothelin, the systolic blood pressure of conscious rats rose on Day 1 to only 137.0 ± 2.4 mm Hg (P <.05) compared to the rise to 163.8 ± 4.7 mm Hg when endothelin alone was infused. The antihypertensive effect of benidipine was sustained. The present results suggest that endothelin can act as a circulating hormone. In addition, they clearly demonstrate that the calcium channel blocker attenuates the elevation of blood pressure induced by endothelin.

Original languageEnglish
Pages (from-to)635-637
Number of pages3
JournalAmerican Journal of Hypertension
Issue number8
Publication statusPublished - 1990 Aug


  • Blood pressure regulation
  • Calcium channel blockers
  • Conscious rats
  • Endothelin

ASJC Scopus subject areas

  • Internal Medicine


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