Chronic effect of norepinephrine, vasopressin and angiotensin n on urinary prostaglandin E and kallikrein excretion in conscious rats

Masaya Tanno, Keishi ABe, Minoru yasujima, Ko Sato, Ken Omata, Makito Sato, Kei Kudo, Kazuo Tsunoda, Masahiro Kohzuki, Satoru Chiba, Kaoru Yoshinaga

Research output: Contribution to journalArticlepeer-review

Abstract

To assess in vivo functional interactions of vasopressor substances, norepinephrine, vasopressin and angiotensin II with renal vasodepressor mechanisms, prostaglandins and kallikrein-kinin systems, we evaluated chronic effects of norepinephrine (1.8 mg/kg/day, ip), vasopressin (7.2 u/kg/day, ip) and angiotensin IE (0. 9 mg/kg/day ip) on urinary excretion of prostaglandin E and kallikrein in conscious rats. Norepinephrine, vasopressin and angiotensin n mduced a sustained increase in systolic blood pressure. Norepinephrine and angiotensin n induced slight but significant increases in urinary prostaglandin E excretion and urinary kallikrein excretion which were sustained for up to 6 days. Vasopressin induced a marked increase in urinary prostaglandin E excretion which was sustained for up to 6 days, whereas it induced a sustained decrease in urinary kallikrein excretion. Circulating angiotensin n level was markedly increased by exogenous angiotensin II, but it was not changed by norepinephrine and was decreased by vasopressin. These results indicate that renal prostaglandin E changes independently of the renal kallikrein-kinin and renin∼angiotensin systems in response to norepinephrine, vasopressin and angiotensin II, and that vasopressin may be a more potent stimulator of the synthesis or release of renal prostaglandin E.

Original languageEnglish
Pages (from-to)825-831
Number of pages7
JournalThe Japanese Journal Of Nephrology
Volume27
Issue number6
DOIs
Publication statusPublished - 1985

Keywords

  • angiotensin I
  • norepinephrine
  • renal kallikrein-kinin system
  • renal prostaglandin E
  • vasopressin

ASJC Scopus subject areas

  • Nephrology

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