Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti–HLA-DP Antibodies Following Living Donor Kidney Transplantation: A Case Report

Kengo Fukuoka, Kazuaki Tokodai, Shigehito Miyagi, Wataru Nakanishi, Ryuichi Nishimura, Atsushi Fujio, Hirofumi Watanabe, Shinji Taniuchi, Takeshi Naitoh, Takanori Ishida, Michiaki Unno, Takashi Kamei

Research output: Contribution to journalArticle

Abstract

Posttransplant donor-specific anti-HLA antibodies (DSA) cause chronic antibody-mediated rejection. Anti-DR and anti-DQ DSAs have especially been shown to be associated with negative graft function. In contrast, the prevalence and significance of anti-DP DSA have not been well established and remain unclear. We report a case of living donor kidney transplantation. The level of serum creatinine gradually became elevated because of chronic active antibody-mediated rejection, which was considered to be caused by anti-DP DSA. In this report, we indicate the significance of pretransplant screening for HLA-DP in donors to evaluate more comprehensively the donor specificity of posttransplant HLA antibodies.

Original languageEnglish
Pages (from-to)1937-1939
Number of pages3
JournalTransplantation Proceedings
Volume52
Issue number6
DOIs
Publication statusPublished - 2020 Jul 1

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Fingerprint Dive into the research topics of 'Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti–HLA-DP Antibodies Following Living Donor Kidney Transplantation: A Case Report'. Together they form a unique fingerprint.

  • Cite this