Chromosomal instability: A common feature and a therapeutic target of cancer

Kozo Tanaka, Toru Hirota

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)

Abstract

Most cancer cells are aneuploid, containing abnormal numbers of chromosomes, mainly caused by elevated levels of chromosome missegregation, known as chromosomal instability (CIN). These well-recognized, but poorly understood, features of cancers have recently been studied extensively, unraveling causal relationships between CIN and cancer. Here we review recent findings regarding how CIN and aneuploidy occur, how they affect cellular functions, how cells respond to them, and their relevance to diseases, especially cancer. Aneuploid cells are under various kinds of stresses that result in reduced cellular fitness. Nevertheless, genetic heterogeneity derived from CIN allows the selection of cells better adapted to their environment, which supposedly facilitates generation and progression of cancer. We also discuss how we can exploit the properties of cancer cells exhibiting CIN for effective cancer therapy.

Original languageEnglish
Pages (from-to)64-75
Number of pages12
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1866
Issue number1
DOIs
Publication statusPublished - 2016 Aug 1

Keywords

  • Aneuploidy
  • Cancer
  • Chromosomal instability
  • Chromosome segregation
  • Kinetochore
  • Mitosis

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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