TY - JOUR
T1 - Chromatin dynamics underlying the precise regeneration of a vertebrate limb – Epigenetic regulation and cellular memory
AU - Hayashi, Shinichi
AU - Tamura, Koji
AU - Yokoyama, Hitoshi
N1 - Funding Information:
This work was supported by JSPS KAKENHI [grant number 17H06905] to SH; Kato Memorial Bioscience Foundation to SH; JSPS KAKENHI [grant number 16H04790] to HY; Hirosaki University Institutional Research Grant for Young investigators to HY; Grant for Basic Science Research Projects from The Sumitomo Foundation to HY; and the Takeda Science Foundation to HY.
PY - 2020/1
Y1 - 2020/1
N2 - Wound healing, tissue regeneration, and organ regrowth are all regeneration phenomena observed in vertebrates after an injury. However, the ability to regenerate differs greatly among species. Mammals can undergo wound healing and tissue regeneration, but cannot regenerate an organ; for example, they cannot regrow an amputated limb. In contrast, amphibians and fish have much higher capabilities for organ-level regeneration. In addition to medical studies and those in conventional mammalian models such as mice, studies in amphibians and fish have revealed essential factors for and mechanisms of regeneration, including the regrowth of a limb, tail, or fin. However, the molecular nature of the cellular memory needed to precisely generate a new appendage from an amputation site is not fully understood. Recent reports have indicated that organ regeneration is closely related to epigenetic regulation. For example, the methylation status of genomic DNA is related to the expression of regeneration-related genes, and histone-modification enzymes are required to control the chromatin dynamics for regeneration. A proposed mechanism of cellular memory involving an inheritable system of epigenetic modification led us to hypothesize that epigenetic regulation forms the basis for cellular memory in organ regeneration. Here we summarize the current understanding of the role of epigenetic regulation in organ regeneration and discuss the relationship between organ regeneration and epigenetic memory.
AB - Wound healing, tissue regeneration, and organ regrowth are all regeneration phenomena observed in vertebrates after an injury. However, the ability to regenerate differs greatly among species. Mammals can undergo wound healing and tissue regeneration, but cannot regenerate an organ; for example, they cannot regrow an amputated limb. In contrast, amphibians and fish have much higher capabilities for organ-level regeneration. In addition to medical studies and those in conventional mammalian models such as mice, studies in amphibians and fish have revealed essential factors for and mechanisms of regeneration, including the regrowth of a limb, tail, or fin. However, the molecular nature of the cellular memory needed to precisely generate a new appendage from an amputation site is not fully understood. Recent reports have indicated that organ regeneration is closely related to epigenetic regulation. For example, the methylation status of genomic DNA is related to the expression of regeneration-related genes, and histone-modification enzymes are required to control the chromatin dynamics for regeneration. A proposed mechanism of cellular memory involving an inheritable system of epigenetic modification led us to hypothesize that epigenetic regulation forms the basis for cellular memory in organ regeneration. Here we summarize the current understanding of the role of epigenetic regulation in organ regeneration and discuss the relationship between organ regeneration and epigenetic memory.
KW - Amelioration of regeneration ability
KW - Cellular memory
KW - Epigenetic regulation
KW - Organ regeneration
KW - Positional information (value)
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U2 - 10.1016/j.semcdb.2019.04.006
DO - 10.1016/j.semcdb.2019.04.006
M3 - Review article
C2 - 30991117
AN - SCOPUS:85065422444
VL - 97
SP - 16
EP - 25
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
ER -