TY - JOUR
T1 - Chlorophagy is ATG gene-dependent microautophagy process
AU - Nakamura, Sakuya
AU - Izumi, Masanori
N1 - Funding Information:
This work was supported, in part, by Japan Society for the Promotion of Science (JSPS) KAKENHI [Grant Numbers 17H05050 and 18H04852 to M.I., 16J03408 to S.N.], the JSPS Research Fellowship for Young Scientists (to S.N.), Japan Science and Technology Agency (JST) PRESTO (Grant Number JPMJPR16Q1 to M.I.), and the Program for Creation of Interdisciplinary Research at Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Japan (to M.I.).
Publisher Copyright:
© 2018, © 2018 Taylor & Francis Group, LLC.
PY - 2019/1/2
Y1 - 2019/1/2
N2 - Autophagy delivers cytosolic components to lysosomes and the vacuole for degradation. This pathway prevents starvation through bulk degradation and recycling of cytoplasmic components, and maintains cellular homeostasis through selective elimination of damaged proteins and organelles. Autophagic delivery processes are categorized into three types: macroautophagy, microautophagy, and chaperone-mediated autophagy. During macroautophagy, nascent, double membrane–bound vesicles termed autophagosomes sequester a portion of cytoplasm and deliver it to the vacuole/lysosomes. Molecular genetic studies in budding yeasts have identified a set of AUTOPHAGY (ATG) genes required for autophagosome formation. Although microautophagy involves the direct lysosomal/vacuolar engulfment and incorporation of a target into the lumen rather than the formation of autophagosomes, the membrane dynamics and possible roles of ATGs during microautophagy are under investigation. Our recent study revealed an ATG-dependent microautophagy process in plants, during which chloroplasts damaged by high visible light (HL) are selectively eliminated. Here, we discuss the membrane dynamics of the plant microautophagy that enables the transport of whole chloroplasts into the vacuole.
AB - Autophagy delivers cytosolic components to lysosomes and the vacuole for degradation. This pathway prevents starvation through bulk degradation and recycling of cytoplasmic components, and maintains cellular homeostasis through selective elimination of damaged proteins and organelles. Autophagic delivery processes are categorized into three types: macroautophagy, microautophagy, and chaperone-mediated autophagy. During macroautophagy, nascent, double membrane–bound vesicles termed autophagosomes sequester a portion of cytoplasm and deliver it to the vacuole/lysosomes. Molecular genetic studies in budding yeasts have identified a set of AUTOPHAGY (ATG) genes required for autophagosome formation. Although microautophagy involves the direct lysosomal/vacuolar engulfment and incorporation of a target into the lumen rather than the formation of autophagosomes, the membrane dynamics and possible roles of ATGs during microautophagy are under investigation. Our recent study revealed an ATG-dependent microautophagy process in plants, during which chloroplasts damaged by high visible light (HL) are selectively eliminated. Here, we discuss the membrane dynamics of the plant microautophagy that enables the transport of whole chloroplasts into the vacuole.
KW - Autophagy
KW - chlorophagy
KW - chloroplast
KW - microautophagy
KW - photodamage
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U2 - 10.1080/15592324.2018.1558679
DO - 10.1080/15592324.2018.1558679
M3 - Article
C2 - 30574829
AN - SCOPUS:85059023284
VL - 14
JO - Plant Signaling and Behavior
JF - Plant Signaling and Behavior
SN - 1559-2316
IS - 1
M1 - 1554469
ER -