Chloride imbalance is involved in the pathogenesis of optic neuritis in neuromyelitis optica

Tetsuya Akaishi, Toshiyuki Takahashi, Noriko Himori, Takayuki Takeshita, Toru Nakazawa, Masashi Aoki, Ichiro Nakashima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Chloride imbalance between the serum and the cerebrospinal fluid (CSF) has been recently shown to exist in the acute phase of neuromyelitis optica (NMO). In this report, we studied the relation between the quotient of chloride (QCl) and the severity of optic neuritis (ON) in NMO patients. There was a positive correlation (R = 0.67; p < 0.05) between QCl and the length of ON-lesion. The visual prognosis also showed a positive correlation with QCl in the acute phase (R = 0.58; p < 0.05). These results support the theory that chloride imbalance between serum and CSF may trigger the ON in NMO spectrum disorders.

Original languageEnglish
Pages (from-to)98-100
Number of pages3
JournalJournal of Neuroimmunology
Volume320
DOIs
Publication statusPublished - 2018 Jul 15

Keywords

  • Chloride imbalance
  • Neuromyelitis optica
  • Optic neuritis
  • Quotient of chloride
  • Visual prognosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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