Chloride imbalance between serum and CSF in the acute phase of neuromyelitis optica

Tetsuya Akaishi, Toshiyuki Takahashi, Ichiro Nakashima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We collected serum-cerebrospinal fluid (CSF)-paired samples during the acute phase of clinical episodes in MS and NMO patients, together with paired samples from non-MS/NMO patients, to compare the quotients of proteins and electrolytes among them. In NMO, the quotient of chloride was significantly higher in the acute phase of optic neuritis and brain lesions, but it was significantly lower in the acute phase of myelitis. Such findings were not observed in MS or in non-MS/NMO cases. With the coexistence of serum anti-AQP4-Ab, chloride imbalance between serum and CSF could be associated with the clinical episodes in NMO.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalJournal of Neuroimmunology
Volume315
DOIs
Publication statusPublished - 2018 Feb 15

Keywords

  • Electrolyte imbalance
  • Myelitis
  • Neuromyelitis optica
  • Optic neuritis
  • Quotient of chloride

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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