Chiral titanium complex-catalyzed carbonyl-ene reaction with glyoxylate: Remarkable positive nonlinear effect

Koichi Mikami, Masahiro Terada

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)

Abstract

The enantioselective glyoxylate-ene reaction catalyzed by chiral titanium complex derived from partially resolved binaphthol (BINOL) is shown to exhibit a remarkable level of asymmetric amplification (positive nonlinear effect). Thus, the optical yield of the ene product significantly exceeds the enantio-purity of the chiral ligand (BINOL).

Original languageEnglish
Pages (from-to)5671-5680
Number of pages10
JournalTetrahedron
Volume48
Issue number27
DOIs
Publication statusPublished - 1992 Jul 3
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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