Chiral tetraazamacrocycles having four pendant-arms

Seiji Kamioka; Takashi Takahashi; Susumu Kawauchi; Hiroaki Adachi; Yusuke Mori; Kotaro Fujii; Hidehiro Uekusa; Takayuki Doi

doi:10.1021/ol9005954

Chiral tetraazamacrocycles having four pendant-arms

Seiji Kamioka, Takashi Takahashi, Susumu Kawauchi, Hiroaki Adachi, Yusuke Mori, Kotaro Fujii, Hidehiro Uekusa, Takayuki Doi

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A chiral tetraazamacrocycle 9 having four pendant-arms was synthesized by repeating ring opening of an Ns-aziridine with secondary amines, followed by macrocyclization. The structure of 9 has been determined by single crystal X-ray diffraction analysis and NMR studies. Sugarhybrid molecules 12a-12f were synthesized based on the scaffold 9. NMR study showed that 12a-12f keep the similar conformation as 9 in solution.

Original language	English
Pages (from-to)	2289-2292
Number of pages	4
Journal	Organic letters
Volume	11
Issue number	11
DOIs	https://doi.org/10.1021/ol9005954
Publication status	Published - 2009 Jun 4

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol9005954

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abstract = "A chiral tetraazamacrocycle 9 having four pendant-arms was synthesized by repeating ring opening of an Ns-aziridine with secondary amines, followed by macrocyclization. The structure of 9 has been determined by single crystal X-ray diffraction analysis and NMR studies. Sugarhybrid molecules 12a-12f were synthesized based on the scaffold 9. NMR study showed that 12a-12f keep the similar conformation as 9 in solution.",

author = "Seiji Kamioka and Takashi Takahashi and Susumu Kawauchi and Hiroaki Adachi and Yusuke Mori and Kotaro Fujii and Hidehiro Uekusa and Takayuki Doi",

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T1 - Chiral tetraazamacrocycles having four pendant-arms

AU - Kamioka, Seiji

AU - Takahashi, Takashi

AU - Kawauchi, Susumu

AU - Adachi, Hiroaki

AU - Mori, Yusuke

AU - Fujii, Kotaro

AU - Uekusa, Hidehiro

AU - Doi, Takayuki

PY - 2009/6/4

Y1 - 2009/6/4

N2 - A chiral tetraazamacrocycle 9 having four pendant-arms was synthesized by repeating ring opening of an Ns-aziridine with secondary amines, followed by macrocyclization. The structure of 9 has been determined by single crystal X-ray diffraction analysis and NMR studies. Sugarhybrid molecules 12a-12f were synthesized based on the scaffold 9. NMR study showed that 12a-12f keep the similar conformation as 9 in solution.

AB - A chiral tetraazamacrocycle 9 having four pendant-arms was synthesized by repeating ring opening of an Ns-aziridine with secondary amines, followed by macrocyclization. The structure of 9 has been determined by single crystal X-ray diffraction analysis and NMR studies. Sugarhybrid molecules 12a-12f were synthesized based on the scaffold 9. NMR study showed that 12a-12f keep the similar conformation as 9 in solution.

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JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 11

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