Chiral strong Brønsted acid-catalyzed enantioselective addition reaction of simple olefins with ethyl glyoxylate

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Abstract

An enantioselective intermolecular carbonyl-ene reaction and a Friedel-Crafts-type reaction of 1,1,2-trisubstituted and 1,2-disubstituted simple olefins with ethyl glyoxylate were developed using F10BINOL-derived N-sulfonyl phosphoramide as the chiral strong Brønsted acid catalyst. The present reactions feature an atom-economical and environmentally benign approach to the synthesis of enantioenriched allylic and homoallylic alcohols.

Original languageEnglish
Pages (from-to)1383-1387
Number of pages5
JournalOrganic Chemistry Frontiers
Volume7
Issue number11
DOIs
Publication statusPublished - 2020 Jun 7

ASJC Scopus subject areas

  • Organic Chemistry

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