Chiral primary amino amide alcohol organocatalyst for the asymmetric Michael addition of 4-hydroxycoumarin with α,β-unsaturated ketones

Jun Kumagai, Yoshihito Kohari, Chigusa Seki, Koji Uwai, Yuko Okuyama, Eunsang Kwon, Hiroto Nakano

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Chiral primary amino amide organocatalysts were designed and synthesized as new organocatalysts for the enantioselective Michael addition of 4-hydroxycoumarin with α,β-unsaturated ketones to produce chiral warfarin (up to 56% ee with up to 92% yield).

Original languageEnglish
Pages (from-to)1124-1134
Number of pages11
JournalHeterocycles
Volume90
Issue number2
DOIs
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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