Abstract
An enantioselective Mannich-type reaction between enamides, serving as aliphatic imine equivalents, and thiazolones or an azlactone, serving as α-amino acid derived pronucleophiles, was investigated using a chiral phosphoric acid catalyst. By using thiazolones, Mannich adducts with a tetrasubstituted chiral carbon center at the α-position and an aliphatic substituent at the β-position were efficiently obtained with high diastereo- and enantioselectivities.
| Original language | English |
|---|---|
| Pages (from-to) | 2521-2523 |
| Number of pages | 3 |
| Journal | Organic letters |
| Volume | 18 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2016 Jun 3 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry