Chiral discrimination in electrocatalytic oxidation of (R)- and (S)-1- phenylethanol using a chiral nitroxyl radical as catalyst

Yoshitomo Kashiwagi, Kazumi Uchiyama, Futoshi Kurashima, Chikara Kikuchi, Jun Ichi Anzai

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

A chiral nitroxyl radical, (6R,7S, 10R)-4-oxo-2,2,7-trimethyl-10- isopropyl-1-azaspiro[5.5]undecane-N-oxyl, was used as catalyst in the electrooxidation reaction of (R)- and (S)-1-phenylethanol. Cyclic voltammetric studies showed that the catalytic current for the oxidation of (R)-1-phenylethanol is highly enhanced as compared with a very small enhancement in the oxidation current for the (S)-isomer. The (R)-isomer can be detected selectively in a mixture of (R)- and (S)-1-phenylethanol, even in the presence of an excess amount of (S)-isomer.

Original languageEnglish
Pages (from-to)1051-1052
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume47
Issue number7
DOIs
Publication statusPublished - 1999 Jul

Keywords

  • Chiral discrimination
  • Chiral nitroxyl radical
  • Cyclic voltammetry
  • Electrocatalytic oxidation

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

Fingerprint Dive into the research topics of 'Chiral discrimination in electrocatalytic oxidation of (R)- and (S)-1- phenylethanol using a chiral nitroxyl radical as catalyst'. Together they form a unique fingerprint.

Cite this