The authors report on a 14-year-old boy who developed T-cell acute lymphoblastic leukemia (FAB:L1) displaying 4 immunophenotypically distinct leukemic cell populations by 3-color immunofluorescence staining. Cytogenetic analysis at diagnosis showed 46, XY, add(4)(p16)/46, XY. A single rearrangement of the T-cell antigen receptor β- and γ-chain genes in these cells indicated monoclonality of the leukemic cells. These findings suggest that leukemic blast cells of monoclonal origin in this case were divided into 4 immunophenotypic populations, representing various stages of differentiation.
- Childhood T-ALL
- Gene rearrangement
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health