Childhood T-cell acute lymphoblastic leukemia with four distinct immunophenotypes representing different stages of T-cell development

H. Harigae, T. Miura, M. Kaku, M. Ouhira, N. Koseki, Y. Obara, S. Fujimaki, M. Imaizumi, J. Kameoka, T. Sasaki, T. Funato

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1 Citation (Scopus)

Abstract

The authors report on a 14-year-old boy who developed T-cell acute lymphoblastic leukemia (FAB:L1) displaying 4 immunophenotypically distinct leukemic cell populations by 3-color immunofluorescence staining. Cytogenetic analysis at diagnosis showed 46, XY, add(4)(p16)[12]/46, XY[2]. A single rearrangement of the T-cell antigen receptor β- and γ-chain genes in these cells indicated monoclonality of the leukemic cells. These findings suggest that leukemic blast cells of monoclonal origin in this case were divided into 4 immunophenotypic populations, representing various stages of differentiation.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalPediatric Hematology and Oncology
Volume18
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • Childhood T-ALL
  • Gene rearrangement
  • Immunophenotype

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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