Childhood T-cell acute lymphoblastic leukemia with four distinct immunophenotypes representing different stages of T-cell development

H. Harigae; T. Miura; M. Kaku; M. Ouhira; N. Koseki; Y. Obara; S. Fujimaki; M. Imaizumi; J. Kameoka; T. Sasaki; T. Funato

doi:10.1080/088800101750238577

Childhood T-cell acute lymphoblastic leukemia with four distinct immunophenotypes representing different stages of T-cell development

H. Harigae, T. Miura, M. Kaku, M. Ouhira, N. Koseki, Y. Obara, S. Fujimaki, M. Imaizumi, J. Kameoka, T. Sasaki, T. Funato

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1 Citation (Scopus)

Abstract

The authors report on a 14-year-old boy who developed T-cell acute lymphoblastic leukemia (FAB:L1) displaying 4 immunophenotypically distinct leukemic cell populations by 3-color immunofluorescence staining. Cytogenetic analysis at diagnosis showed 46, XY, add(4)(p16)[12]/46, XY[2]. A single rearrangement of the T-cell antigen receptor β- and γ-chain genes in these cells indicated monoclonality of the leukemic cells. These findings suggest that leukemic blast cells of monoclonal origin in this case were divided into 4 immunophenotypic populations, representing various stages of differentiation.

Original language	English
Pages (from-to)	267-272
Number of pages	6
Journal	Pediatric Hematology and Oncology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1080/088800101750238577
Publication status	Published - 2001

Keywords

Childhood T-ALL
Gene rearrangement
Immunophenotype

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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Harigae, H., Miura, T., Kaku, M., Ouhira, M., Koseki, N., Obara, Y., Fujimaki, S., Imaizumi, M., Kameoka, J., Sasaki, T., & Funato, T. (2001). Childhood T-cell acute lymphoblastic leukemia with four distinct immunophenotypes representing different stages of T-cell development. Pediatric Hematology and Oncology, 18(4), 267-272. https://doi.org/10.1080/088800101750238577

Harigae, H, Miura, T, Kaku, M, Ouhira, M, Koseki, N, Obara, Y, Fujimaki, S, Imaizumi, M, Kameoka, J, Sasaki, T & Funato, T 2001, 'Childhood T-cell acute lymphoblastic leukemia with four distinct immunophenotypes representing different stages of T-cell development', Pediatric Hematology and Oncology, vol. 18, no. 4, pp. 267-272. https://doi.org/10.1080/088800101750238577

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abstract = "The authors report on a 14-year-old boy who developed T-cell acute lymphoblastic leukemia (FAB:L1) displaying 4 immunophenotypically distinct leukemic cell populations by 3-color immunofluorescence staining. Cytogenetic analysis at diagnosis showed 46, XY, add(4)(p16)[12]/46, XY[2]. A single rearrangement of the T-cell antigen receptor β- and γ-chain genes in these cells indicated monoclonality of the leukemic cells. These findings suggest that leukemic blast cells of monoclonal origin in this case were divided into 4 immunophenotypic populations, representing various stages of differentiation.",

keywords = "Childhood T-ALL, Gene rearrangement, Immunophenotype",

author = "H. Harigae and T. Miura and M. Kaku and M. Ouhira and N. Koseki and Y. Obara and S. Fujimaki and M. Imaizumi and J. Kameoka and T. Sasaki and T. Funato",

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doi = "10.1080/088800101750238577",

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T1 - Childhood T-cell acute lymphoblastic leukemia with four distinct immunophenotypes representing different stages of T-cell development

AU - Harigae, H.

AU - Miura, T.

AU - Kaku, M.

AU - Ouhira, M.

AU - Koseki, N.

AU - Obara, Y.

AU - Fujimaki, S.

AU - Imaizumi, M.

AU - Kameoka, J.

AU - Sasaki, T.

AU - Funato, T.

PY - 2001

Y1 - 2001

N2 - The authors report on a 14-year-old boy who developed T-cell acute lymphoblastic leukemia (FAB:L1) displaying 4 immunophenotypically distinct leukemic cell populations by 3-color immunofluorescence staining. Cytogenetic analysis at diagnosis showed 46, XY, add(4)(p16)[12]/46, XY[2]. A single rearrangement of the T-cell antigen receptor β- and γ-chain genes in these cells indicated monoclonality of the leukemic cells. These findings suggest that leukemic blast cells of monoclonal origin in this case were divided into 4 immunophenotypic populations, representing various stages of differentiation.

AB - The authors report on a 14-year-old boy who developed T-cell acute lymphoblastic leukemia (FAB:L1) displaying 4 immunophenotypically distinct leukemic cell populations by 3-color immunofluorescence staining. Cytogenetic analysis at diagnosis showed 46, XY, add(4)(p16)[12]/46, XY[2]. A single rearrangement of the T-cell antigen receptor β- and γ-chain genes in these cells indicated monoclonality of the leukemic cells. These findings suggest that leukemic blast cells of monoclonal origin in this case were divided into 4 immunophenotypic populations, representing various stages of differentiation.

KW - Childhood T-ALL

KW - Gene rearrangement

KW - Immunophenotype

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JF - Pediatric Hematology and Oncology

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Childhood T-cell acute lymphoblastic leukemia with four distinct immunophenotypes representing different stages of T-cell development

Abstract

Keywords

ASJC Scopus subject areas

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