Chemospecific allylation and domino metathesis of 7-oxanorbornenes for skeletal and appendage diversity

Minoru Ikoma, Masato Oikawa, Makoto Sasaki

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

We report a synthetic strategy for skeletally diverse heterocycles featuring appendage diversity based on a tandem Ugi/ Diels-Alder reaction followed by domino metathesis. An associating effect of the amide carbonyl functionality to the ruthenium metal center is proposed in order to account for the difference in the metathesis yields.

Original languageEnglish
Pages (from-to)72-84
Number of pages13
JournalEuropean Journal of Organic Chemistry
Issue number1
DOIs
Publication statusPublished - 2009 Jan

Keywords

  • Alkylation
  • Combinatorial chemistry
  • Domino reactions
  • Metathesis
  • Multicomponent reactions

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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