Abstract
We report a synthetic strategy for skeletally diverse heterocycles featuring appendage diversity based on a tandem Ugi/ Diels-Alder reaction followed by domino metathesis. An associating effect of the amide carbonyl functionality to the ruthenium metal center is proposed in order to account for the difference in the metathesis yields.
Original language | English |
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Pages (from-to) | 72-84 |
Number of pages | 13 |
Journal | European Journal of Organic Chemistry |
Issue number | 1 |
DOIs | |
Publication status | Published - 2009 Jan |
Keywords
- Alkylation
- Combinatorial chemistry
- Domino reactions
- Metathesis
- Multicomponent reactions
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry