Chemopreventive effects of Ginkgo biloba extract in estrogen-negative human breast cancer cells

Yong Joo Park, Mi Jie Kim, Ha Ryong Kim, Min Sun Yi, Kyu Hyuck Chung, Seung Min Oh

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Excessive level of estrogen is considered as a main cause of breast cancer, therefore, many studies have focused on estrogen receptor (ER)-positive breast cancer, even though ER-negative cancer has a poor prognosis than ER-positive breast cancer. We evaluated the anti-cancer effects of Ginkgo biloba extract (GBE) in estrogen-independent breast cancer. GBE has been traditionally used as a platelet activating factor, a circulatory stimulant, a tonic, and anti-asthmatic drug, and anti-cancer agent. However, anti-cancer effects of GBE on ER-negative breast cancer have not been proved yet. In this study, we tested chemotherapeutic potential of GBE in the MDA-MB-231 (ER-negative) human breast cancer cell line. Our results showed that cytotoxicity effects of GBE in MDA-MB-231 lead to DNA fragmentation at high concentrations (500 and 1,000 μg/ml). Caspase-3 was significantly activated and mRNA levels of apoptosis-related genes (Bcl-2 and Bax) were altered. These results indicate that GBE induces apoptosis in MDA-MB-231 cells. It is presumed that GBE has chemopreventive effects in ER-independent breast cancer through anti-proliferation and apoptosis-inducing activities.

Original languageEnglish
Pages (from-to)102-108
Number of pages7
JournalArchives of Pharmacal Research
Volume36
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

Keywords

  • Apoptosis
  • Breast cancer
  • Ginkgo biloba extract
  • MDA-MB-231 cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Chemopreventive effects of Ginkgo biloba extract in estrogen-negative human breast cancer cells'. Together they form a unique fingerprint.

Cite this