Chemokines: Roles in leukocyte development, trafficking, and effector function

Santa Jeremy Ono, Takao Nakamura, Dai Miyazaki, Masaharu Ohbayashi, Maria Dawson, Masako Toda

Research output: Contribution to journalReview articlepeer-review

187 Citations (Scopus)

Abstract

Chemokines, representing a large superfamily of 8- to 15-kd proteins, were originally discovered through their ability to recruit various cell types into sites of inflammation. It is now clear that these molecules play a much wider role in immune homeostasis, playing key roles in driving the maturation, homing, and activation of leukocytes. In this review we analyze the roles chemokines play in the development, recruitment, and activation of leukocytes. Because signaling from the receptors drives these processes, signal transduction from chemokine receptors will also be reviewed. Taken together, we highlight the various points at which chemokines contribute to allergic inflammation and at which their targeting might contribute to new therapies for type I hypersensitivity reactions.

Original languageEnglish
Pages (from-to)1185-1199
Number of pages15
JournalJournal of Allergy and Clinical Immunology
Volume111
Issue number6
DOIs
Publication statusPublished - 2003 Jun 1
Externally publishedYes

Keywords

  • Allergy
  • Asthma
  • Chemokines
  • Receptors
  • Signal transduction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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