Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada disease

Isabelle Miyazawa, Toshiaki Abe, Koichi Narikawa, Juan Feng, Tatsuro Misu, Ichiro Nakashima, Juichi Fujimori, Makoto Tamai, Kazuo Fujihara, Yasuto Itoyama

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

We analyzed the concentrations of four chemokines in the cerebrospinal fluid (CSF) and sera in Vogt-Koyanagi-Harada disease (VKH), an autoimmune uveomeningitis syndrome against melanocyte-associated proteins, with ELISA. CSF-CXCL10/IP-10 and CSF-CCL17/TARC were significantly elevated in VKH than in controls. In the majority of VKH cases and controls, CSF-CXCL10 was higher than serum-CXCL10, and CSF-CCL17 was lower than serum-CCL17. CCL11/Eotaxin was not different between groups. CSF-CCL2/MCP-1 was significantly lower in VKH than in control. The changes in VKH were essentially similar to those in multiple sclerosis, a known Th1-dominant condition.

Original languageEnglish
Pages (from-to)240-244
Number of pages5
JournalJournal of Neuroimmunology
Volume158
Issue number1-2
DOIs
Publication statusPublished - 2005 Jan

Keywords

  • Chemokine
  • Uveitis
  • Vogt-Koyanagi-Harada disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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