Chemo-thermal approach for efficient ultrasonic tumor treatment with phase change nano droplet

Kenichi Kawabata, Rei Asami, Shinichiro Umemura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Phase-change nano-droplet (PCND) was found to promote chemically significant cavitation. PCNDs, which were droplets containing superheated perfluorocarbon and suspended in buffer solution with potassium iodide, were exposed to 1.1-MHz ultrasound with a sequence of periodically applied triggering pulses to generate microbubbles and following continuous-wave (CW) exposures. The chemical activity of ultrasound exposures, measured as the reaction yield of tri-iodide ions was strongly dependent on the interval of the pulses. We found that pulse intervals shorter than 0.03 s were needed to generate chemically significant cavitation. Further, we found that pre-exposure of ultrasound for chemical effects could be performed by using gel phantoms with thermal coagulation indicators, without sacrificing the effect of PCNDs to enhance temperature increase induced by exposure to high intensity focused ultrasound (HIFU). The results we obtained suggested the potential of 'chemo-thermal' therapy for tumors, which sequentially utilizes the chemical and thermal effect of PCNDs.

Original languageEnglish
Title of host publication2011 IEEE International Ultrasonics Symposium, IUS 2011
Pages9-12
Number of pages4
DOIs
Publication statusPublished - 2011 Dec 1
Event2011 IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, FL, United States
Duration: 2011 Oct 182011 Oct 21

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2011 IEEE International Ultrasonics Symposium, IUS 2011
CountryUnited States
CityOrlando, FL
Period11/10/1811/10/21

Keywords

  • cavitation
  • chemical effects
  • microbubble
  • nano droplet
  • phase-change

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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