Chemicofunctional membrane for integrated chemical processes on a microchip

Hideaki Hisamoto, Yuki Shimizu, Kenji Uchiyama, Manabu Tokeshi, Yoshikuni Kikutani, Akihide Hibara, Takehiko Kitamori

Research output: Contribution to journalArticlepeer-review

143 Citations (Scopus)


Here we report a design and synthesis of a chemically functional polymer membrane by an interfacial polycondensation reaction and multilayer flow inside a microchannel. Single and parallel dual-membrane structures are successfully prepared by using organic/aqueous two-layer flow and organic/aqueous/organic three-layer flow inside the microchannel followed by an interfacial polycondensation reaction. By using the inner-channel membrane, permeation of ammonia species through the inner-channel membrane is successfully achieved. Furthermore, horseradish peroxidase is immobilized on one side of the membrane surface to integrate the chemical transform function onto the inner-channel membrane. Here substrate permeation through the membrane and subsequent chemical transformation at the membrane surface are realized. The polymer membrane prepared inside the microchannel has an important role in ensuring stable contact of different phases such as gas/liquid or liquid/ liquid and the permeation of chemical species through the membrane. Furthermore, membrane surface modification chemistry allows chemical transformation of permeated chemical species. These methods are expected to lead to development of complicated and sophisticated chemical systems involving membrane permeation and chemical reactions.

Original languageEnglish
Pages (from-to)350-354
Number of pages5
JournalAnalytical Chemistry
Issue number2
Publication statusPublished - 2003 Jan 15
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry


Dive into the research topics of 'Chemicofunctional membrane for integrated chemical processes on a microchip'. Together they form a unique fingerprint.

Cite this